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Design, study quality and evidence of analgesic efficacy in studies of drugs in models of OA pain: a systematic review and a meta-analysis  A.K. Suokas,

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Presentation on theme: "Design, study quality and evidence of analgesic efficacy in studies of drugs in models of OA pain: a systematic review and a meta-analysis  A.K. Suokas,"— Presentation transcript:

1 Design, study quality and evidence of analgesic efficacy in studies of drugs in models of OA pain: a systematic review and a meta-analysis  A.K. Suokas, D.R. Sagar, P.I. Mapp, V. Chapman, D.A. Walsh  Osteoarthritis and Cartilage  Volume 22, Issue 9, Pages (September 2014) DOI: /j.joca Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

2 Fig. 1 Flow diagram of study selection.
Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

3 Fig. 2 Pooled SMDs and 95% CIs for the analgesic treatment effect of NSAIDs and opioids, by pain modality. Positive increasing SMDs indicate analgesic efficacy. Thermally-evoked pain with only two observations from one study was excluded from the analysis. One study may involve the testing of more than one pain modality and/or drug. Forest plots for each subgroup are presented in Appendix 5. Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

4 Fig. 3 Funnel plot for the magnitude of the analgesic treatment effect (n = 102). Test for publication bias: Egger's test = 5.04 (95% CI = 3.72–6.36) P <  Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

5 Osteoarthritis and Cartilage 2014 22, 1207-1223DOI: (10. 1016/j. joca
Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

6 Osteoarthritis and Cartilage 2014 22, 1207-1223DOI: (10. 1016/j. joca
Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

7 Osteoarthritis and Cartilage 2014 22, 1207-1223DOI: (10. 1016/j. joca
Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

8 Osteoarthritis and Cartilage 2014 22, 1207-1223DOI: (10. 1016/j. joca
Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

9 Osteoarthritis and Cartilage 2014 22, 1207-1223DOI: (10. 1016/j. joca
Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

10 Osteoarthritis and Cartilage 2014 22, 1207-1223DOI: (10. 1016/j. joca
Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions


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