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Incomplete digestion of codfish represents a risk factor for anaphylaxis in patients with allergy  Eva Untersmayr, MD, Helle Vestergaard, Hans-Jørgen.

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Presentation on theme: "Incomplete digestion of codfish represents a risk factor for anaphylaxis in patients with allergy  Eva Untersmayr, MD, Helle Vestergaard, Hans-Jørgen."— Presentation transcript:

1 Incomplete digestion of codfish represents a risk factor for anaphylaxis in patients with allergy 
Eva Untersmayr, MD, Helle Vestergaard, Hans-Jørgen Malling, MD, Louise Bjerremann Jensen, MSc, Michael H. Platzer, PhD, George Boltz-Nitulescu, PhD, Otto Scheiner, PhD, Per Stahl Skov, MD, PhD, Erika Jensen-Jarolim, MD, Lars K. Poulsen, PhD  Journal of Allergy and Clinical Immunology  Volume 119, Issue 3, Pages (March 2007) DOI: /j.jaci Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Time dependency of codfish absorption in healthy individuals. Serum samples drawn 10, 30, 60, 120, and 180 minutes after a codfish meal were analyzed for histamine release capacity with passively sensitized basophils. The quantity of circulating codfish antigen is relatively represented by the amount of released histamine. Data from 3 subjects are presented as means ± SDs. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Codfish proteins are exclusively digested in SGF at low pH. Codfish SPT substance (A,1) and codfish protein extract for DBPCFC (B,1) were subjected to gastric digestion assays at acidic (pH 2.0; 2-4) and hypoacidic conditions (pH 3.0; 5-7) for 1 minute (2, 5), 15 minutes (3, 6), and 2 hours (4, 7). Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Gastric digestion reduces capacity of codfish allergens to trigger skin reactions. SPTs were performed with undigested substances (1-4) or samples digested at pH 2.0 (5-9) and pH 3.0 (10-14) for 1 minute (5-7 and 10-12), 15 minutes (8, 13), and 2 hours (9, 14; dark grey), diluted 1:10 (2, 6, 11), 1:100 (3, 7, 12), and 1:1000 (4; light grey). Boxes represent the size of wheal reactions of 5 patients with codfish allergy (∗P = .009; ∗∗P = .016). Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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