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J.L. Huebner, M.S., V.B. Kraus, M.D., Ph.D. 

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Presentation on theme: "J.L. Huebner, M.S., V.B. Kraus, M.D., Ph.D. "— Presentation transcript:

1 Assessment of the utility of biomarkers of osteoarthritis in the guinea pig 
J.L. Huebner, M.S., V.B. Kraus, M.D., Ph.D.  Osteoarthritis and Cartilage  Volume 14, Issue 9, Pages (September 2006) DOI: /j.joca Copyright © 2006 OsteoArthritis Research Society International Terms and Conditions

2 Fig. 1 Histological progression of OA from 4 to 12 months of age in the Hartley guinea pig. The dashed line represents the mean total histological score of the 12-month-old Strain 13 guinea pigs. Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2006 OsteoArthritis Research Society International Terms and Conditions

3 Fig. 2 Synovial fluid concentrations of KS and COMP in the Hartley strain from 4 to 12 months of age (A and C) and in Hartley (H) and Strain 13 (S) guinea pigs at 2 and 12 months of age (B and D). The asterisk (*) denotes a P-value <0.05 compared to the age-matched Strain 13. The data for KS in (B) have been previously reported4 but are included here to enhance the interpretation of the data as a whole. Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2006 OsteoArthritis Research Society International Terms and Conditions

4 Fig. 3 Serum concentrations of C2C (A and B), CPII (C and D) and C2C/CPII (E and F) in the Hartley strain from 4 to 12 months of age (A, C, and E) and in Hartley (H) and Strain 13 (S) guinea pigs at 2 and 12 months of age (B, D, and F). The asterisk (*) denotes a P-value <0.05 compared to the age-matched Strain 13. Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2006 OsteoArthritis Research Society International Terms and Conditions


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