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Radiotherapy Rescue of a Nivolumab-Refractory Immune Response in a Patient with PD-L1–Negative Metastatic Squamous Cell Carcinoma of the Lung  Zhigang.

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Presentation on theme: "Radiotherapy Rescue of a Nivolumab-Refractory Immune Response in a Patient with PD-L1–Negative Metastatic Squamous Cell Carcinoma of the Lung  Zhigang."— Presentation transcript:

1 Radiotherapy Rescue of a Nivolumab-Refractory Immune Response in a Patient with PD-L1–Negative Metastatic Squamous Cell Carcinoma of the Lung  Zhigang Yuan, MD, PhD, Allison Fromm, ARNP, Kamran A. Ahmed, MD, George D. Grass, MD, PhD, George Q. Yang, MD, Daniel E. Oliver, MD, Thomas J. Dilling, MD, Scott J. Antonia, MD, PhD, Bradford A. Perez, MD  Journal of Thoracic Oncology  Volume 12, Issue 9, Pages e135-e136 (September 2017) DOI: /j.jtho Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

2 Figure 1 Diagnostic and radiotherapy simulation imaging throughout the disease course. Axial computed tomography images are shown, corresponding to the time line showing therapy and disease status. Magenta circles indicate the left apical pleura–based lung mass, teal circles indicate the left retroperitoneal lymph node, and red circles indicate the dominant left anterior perihilar primary lung tumor. Disease response outside of the radiation field is seen after thoracic radiotherapy with a decreased left apical lung mass and left retroperitoneal lymph node after palliative thoracic radiotherapy. The response was durable, as shown by images 2 and 4 months after thoracic radiation. Radiation isodose lines represent total doses of 3000 cGy (red), 2000 cGy (yellow), and 1000 cGy (magenta) (D [lower panel]). Journal of Thoracic Oncology  , e135-e136DOI: ( /j.jtho ) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

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