Presentation is loading. Please wait.

Presentation is loading. Please wait.

Total ion current-EMS chromatograms of SB939 and its metabolites after incubation in liver microsomal fractions for 60 min at a concentration of 50 μM.

Published byΚλυταιμνήστρα Μένθη Λιάπης Modified over 5 years ago

Similar presentations

Presentation on theme: "Total ion current-EMS chromatograms of SB939 and its metabolites after incubation in liver microsomal fractions for 60 min at a concentration of 50 μM."— Presentation transcript:

1 Total ion current-EMS chromatograms of SB939 and its metabolites after incubation in liver microsomal fractions for 60 min at a concentration of 50 μM. Total ion current-EMS chromatograms of SB939 and its metabolites after incubation in liver microsomal fractions for 60 min at a concentration of 50 μM. A, human liver microsomes. B, mouse liver microsomes. C, dog liver microsomes. D, rat liver microsomes. The major metabolite peaks are identified. Ramesh Jayaraman et al. Drug Metab Dispos 2011;39: Copyright © 2011 by The American Society for Pharmacology and Experimental Therapeutics

Download ppt "Total ion current-EMS chromatograms of SB939 and its metabolites after incubation in liver microsomal fractions for 60 min at a concentration of 50 μM."

Similar presentations

Comparative preclinical drug metabolism and pharmacokinetic evaluation of novel 4- aminoquinoline anti-malarials  Charles B. Davis, Ramesh Bambal, Ganesh.

Comparative preclinical drug metabolism and pharmacokinetic evaluation of novel 4- aminoquinoline anti-malarials  Charles B. Davis, Ramesh Bambal, Ganesh.
From: Methoxycarbonyl-etomidate:A Novel Rapidly Metabolized and Ultra–short-acting Etomidate Analogue that Does Not Produce Prolonged Adrenocortical Suppression.

From: Methoxycarbonyl-etomidate:A Novel Rapidly Metabolized and Ultra–short-acting Etomidate Analogue that Does Not Produce Prolonged Adrenocortical Suppression.
Representative 10-s EEG recordings from GAERS: during baseline (prior to injection of any drug) (i), following the i.c.v. injection of 4 μl of vehicle.

Representative 10-s EEG recordings from GAERS: during baseline (prior to injection of any drug) (i), following the i.c.v. injection of 4 μl of vehicle.
Plasma insulin concentrations (A) and insulin secretion rates (B) in response to molar increments of plasma glucose concentration during the graded glucose.

Plasma insulin concentrations (A) and insulin secretion rates (B) in response to molar increments of plasma glucose concentration during the graded glucose.
Comparison of the model incorporating daily dose to that incorporating Cmax. Comparison of the model incorporating daily dose to that incorporating Cmax.

Comparison of the model incorporating daily dose to that incorporating Cmax. Comparison of the model incorporating daily dose to that incorporating Cmax.
Effects of cytokines on P450 mRNA expression in human hepatocytes.

Effects of cytokines on P450 mRNA expression in human hepatocytes.
Evaluation of models incorporating the base covariates.

Evaluation of models incorporating the base covariates.
Nitrate Ion Concentrations

Nitrate Ion Concentrations
The context-sensitive half-times for commonly used intravenous anesthetic drugs. [Reproduced from Reves JG, Glass PSA, Lubarsky DA, McEvoy MD, and Martinez-Ruiz.

The context-sensitive half-times for commonly used intravenous anesthetic drugs. [Reproduced from Reves JG, Glass PSA, Lubarsky DA, McEvoy MD, and Martinez-Ruiz.
(A) (E) (B) (C) (F) (D) Control HLM MLM Chemical synthesis M6

(A) (E) (B) (C) (F) (D) Control HLM MLM Chemical synthesis M6
Formation and metabolism of DOPAL and DOPEGAL

Formation and metabolism of DOPAL and DOPEGAL
A, reversed phase HPLC separation and profile of products from HUVEC and human PMN coincubations. A, reversed phase HPLC separation and profile of products.

A, reversed phase HPLC separation and profile of products from HUVEC and human PMN coincubations. A, reversed phase HPLC separation and profile of products.
Representative radio-HPLC chromatograms for individual pooled methanolic fecal extracts for periods of maximum recovery of radioactivity after dosing of.

Representative radio-HPLC chromatograms for individual pooled methanolic fecal extracts for periods of maximum recovery of radioactivity after dosing of.
HPLC tracings of resveratrol (RV) and its major sulfate conjugates M4/M5 in the plasma from three subjects. HPLC tracings of resveratrol (RV) and its major.

HPLC tracings of resveratrol (RV) and its major sulfate conjugates M4/M5 in the plasma from three subjects. HPLC tracings of resveratrol (RV) and its major.
(A) (E) (B) (C) (F) (D) Control HLM MLM Chemical synthesis M2 M2'

(A) (E) (B) (C) (F) (D) Control HLM MLM Chemical synthesis M2 M2'
Mean (± S.E.) change from baseline in the 6-min walk distance for bosentan (n = 21) and placebo (n = 11) groups. Mean (± S.E.) change from baseline in.

Mean (± S.E.) change from baseline in the 6-min walk distance for bosentan (n = 21) and placebo (n = 11) groups. Mean (± S.E.) change from baseline in.
Structure of solid lipid nanoparticles (SLNs).

Structure of solid lipid nanoparticles (SLNs).
(A) (E) (B) (C) (F) (D) Control HLM MLM Chemical synthesis M4 M4'

(A) (E) (B) (C) (F) (D) Control HLM MLM Chemical synthesis M4 M4'
The three primary ADC components that determine which cells are targeted (antibody), how the drug is released (linker/trigger), and the mechanism of action.

The three primary ADC components that determine which cells are targeted (antibody), how the drug is released (linker/trigger), and the mechanism of action.
(E) (A) (B) (C) (F) (D) Control HLM MLM Chemical synthesis M3'' M3'''

(E) (A) (B) (C) (F) (D) Control HLM MLM Chemical synthesis M3'' M3'''

Similar presentations

Ads by Google