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Risk of Gastrointestinal Bleeding in Patients Taking Non–Vitamin K Antagonist Oral Anticoagulants: A Systematic Review and Meta-analysis  Corey S. Miller,

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Presentation on theme: "Risk of Gastrointestinal Bleeding in Patients Taking Non–Vitamin K Antagonist Oral Anticoagulants: A Systematic Review and Meta-analysis  Corey S. Miller,"— Presentation transcript:

1 Risk of Gastrointestinal Bleeding in Patients Taking Non–Vitamin K Antagonist Oral Anticoagulants: A Systematic Review and Meta-analysis  Corey S. Miller, Alastair Dorreen, Myriam Martel, Thao Huynh, Alan N. Barkun  Clinical Gastroenterology and Hepatology  Volume 15, Issue 11, Pages e3 (November 2017) DOI: /j.cgh Copyright © 2017 AGA Institute Terms and Conditions

2 Figure 1 Flowchart of the literature search and study selection.
Clinical Gastroenterology and Hepatology  , e3DOI: ( /j.cgh ) Copyright © 2017 AGA Institute Terms and Conditions

3 Figure 2 Forest plot of major gastrointestinal bleeding, non–vitamin k antagonist oral anticoagulant vs conventional therapy. Clinical Gastroenterology and Hepatology  , e3DOI: ( /j.cgh ) Copyright © 2017 AGA Institute Terms and Conditions

4 Figure 3 Forest plot of major gastrointestinal bleeding by individual non–vitamin k antagonist oral anticoagulant. (A) Dabigatran vs conventional therapy. (B) Rivaroxaban vs conventional therapy. Clinical Gastroenterology and Hepatology  , e3DOI: ( /j.cgh ) Copyright © 2017 AGA Institute Terms and Conditions

5 Figure 4 Forest plot of major gastrointestinal bleeding by individual non–vitamin k antagonist oral anticoagulant. (A) Apixaban vs conventional therapy. (B) Edoxaban vs conventional therapy. Clinical Gastroenterology and Hepatology  , e3DOI: ( /j.cgh ) Copyright © 2017 AGA Institute Terms and Conditions

6 Supplementary Figure 1 Potential bias of included studies using the Cochrane Risk Bias Tool. Clinical Gastroenterology and Hepatology  , e3DOI: ( /j.cgh ) Copyright © 2017 AGA Institute Terms and Conditions

7 Supplementary Figure 2 Forest plot of major gastrointestinal bleeding, novel oral anticoagulant vs conventional therapy, and hazard ratios. IV, instrumental variables. Clinical Gastroenterology and Hepatology  , e3DOI: ( /j.cgh ) Copyright © 2017 AGA Institute Terms and Conditions


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