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Approach to the true resistant hypertensive and treatment approaches

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1 Approach to the true resistant hypertensive and treatment approaches
Matthew Weir  Journal of Indian College of Cardiology  Volume 5, Pages S33-S37 (March 2015) DOI: /j.jicc Copyright © Terms and Conditions

2 Fig. 1 Plasma aldosterone levels by body weight and BP status.
Journal of Indian College of Cardiology 2015 5, S33-S37DOI: ( /j.jicc ) Copyright © Terms and Conditions

3 Fig. 2 Prevalence of obstructive sleep apnea.
Source: Logan AG, et al. J Hypertens Dec;19:2271–2277 Journal of Indian College of Cardiology 2015 5, S33-S37DOI: ( /j.jicc ) Copyright © Terms and Conditions

4 Fig. 3 Nocturnal continuous positive airway pressure effect on (a) systolic BP and (b) diastolic BP over 24 h – baseline (white bars) and after 2 months (shaded bars). PAC – Plasma aldosterone concentration, PA – Primary aldosteronism. Source: Logan AG et al. Eur Respir J Feb;21:241–247 Journal of Indian College of Cardiology 2015 5, S33-S37DOI: ( /j.jicc ) Copyright © Terms and Conditions

5 Fig. 4 Aldosterone levels and risk of OSA in resistant hypertensive patients. Source: Calhoun DA, et al. Chest Jan;125:112–117 Journal of Indian College of Cardiology 2015 5, S33-S37DOI: ( /j.jicc ) Copyright © Terms and Conditions

6 Fig. 5 (a) AHI and HI correlation with plasma aldosterone levels in resistant hypertension patients (AHI: rho = 0.44, p=0.0002; HI: rho = 0.38, p=0.001). (b)AHI and HI correlation with plasma aldosterone levels in normal patients (AHI: rho = 0.12, p=0.52; HI: rho = 0.002, p=0.99). Source: Pratt-Ubunama MN,et al. Chest Feb;131:453–459 Journal of Indian College of Cardiology 2015 5, S33-S37DOI: ( /j.jicc ) Copyright © Terms and Conditions

7 Fig. 6 Effect of spironolactone on AHI in patients with resistant hypertension and moderate-severe OSA. Journal of Indian College of Cardiology 2015 5, S33-S37DOI: ( /j.jicc ) Copyright © Terms and Conditions


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