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Volume 115, Issue 3, Pages 19S-23S (March 1999)

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Presentation on theme: "Volume 115, Issue 3, Pages 19S-23S (March 1999)"— Presentation transcript:

1 Volume 115, Issue 3, Pages 19S-23S (March 1999)
Pharmacodynamic Principles of Antimicrobial Therapy in the Prevention of Resistance  Burgess David S. , Pharm D  CHEST  Volume 115, Issue 3, Pages 19S-23S (March 1999) DOI: /chest.115.suppl_1.19S Copyright © 1999 The American College of Chest Physicians Terms and Conditions

2 Figure 1 Clinical pharmacology of antimicrobial therapy.
CHEST  , 19S-23SDOI: ( /chest.115.suppl_1.19S) Copyright © 1999 The American College of Chest Physicians Terms and Conditions

3 Figure 2 Relationship between the maximal peak plasma level to MIC ratio and the rate of clinical response in 236 patients with Gram-negative bacterial infection treated with aminoglycosides (gentamicin, tobramycin, or amikacin). Vertical bars represent SE values. From Moore et al,8 with permission. CHEST  , 19S-23SDOI: ( /chest.115.suppl_1.19S) Copyright © 1999 The American College of Chest Physicians Terms and Conditions

4 Figure 3 Pharmacodynamics of β-lactams: the relationship between the time above MIC against S pneumoniae (open symbols) and Haemophilus influenzae (closed symbols) and bacteriologic cure. From Craig and Andes,18 with permission. CHEST  , 19S-23SDOI: ( /chest.115.suppl_1.19S) Copyright © 1999 The American College of Chest Physicians Terms and Conditions


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