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Efficacy and safety of guselkumab, an anti-interleukin-23 monoclonal antibody, compared with adalimumab for the treatment of patients with moderate to.

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Presentation on theme: "Efficacy and safety of guselkumab, an anti-interleukin-23 monoclonal antibody, compared with adalimumab for the treatment of patients with moderate to."— Presentation transcript:

1 Efficacy and safety of guselkumab, an anti-interleukin-23 monoclonal antibody, compared with adalimumab for the treatment of patients with moderate to severe psoriasis with randomized withdrawal and retreatment: Results from the phase III, double-blind, placebo- and active comparator–controlled VOYAGE 2 trial  Kristian Reich, MD, April W. Armstrong, MD, MPH, Peter Foley, MD, Michael Song, MD, Yasmine Wasfi, MD, PhD, Bruce Randazzo, MD, PhD, Shu Li, PhD, Y.-K. Shen, PhD, Kenneth B. Gordon, MD  Journal of the American Academy of Dermatology  Volume 76, Issue 3, Pages (March 2017) DOI: /j.jaad Copyright © 2016 American Academy of Dermatology, Inc. Terms and Conditions

2 Fig 1 Psoriasis. Study schema. ∗Patients initiated guselkumab upon loss of 50% or greater of week-28 Psoriasis Area and Severity Index (PASI) response. Journal of the American Academy of Dermatology  , DOI: ( /j.jaad ) Copyright © 2016 American Academy of Dermatology, Inc. Terms and Conditions

3 Fig 2 Psoriasis. Consolidated Standards of Reporting Trials diagram. PASI 90, 90% or greater improvement in Psoriasis Area and Severity Index score from baseline. Journal of the American Academy of Dermatology  , DOI: ( /j.jaad ) Copyright © 2016 American Academy of Dermatology, Inc. Terms and Conditions

4 Fig 3 Psoriasis. Clinical efficacy from weeks 0 to 24. IGA 0/1, Investigator Global Assessment score of cleared (0) or minimal (1); IGA 0, Investigator Global Assessment score of 0 (cleared); PASI 75, 75% or greater improvement in Psoriasis Area and Severity Index score from baseline; PASI 90, 90% or greater improvement in Psoriasis Area and Severity Index score from baseline; PASI 100, 100% improvement in Psoriasis Area and Severity Index score from baseline. Journal of the American Academy of Dermatology  , DOI: ( /j.jaad ) Copyright © 2016 American Academy of Dermatology, Inc. Terms and Conditions

5 Fig 4 Psoriasis. Clinical efficacy in guselkumab maintenance and withdrawal cases from weeks 28 to 48. IGA 0/1, Investigator Global Assessment score of cleared (0) or minimal (1); IGA 0, Investigator Global Assessment score of 0 (cleared), PASI 75, 75% or greater improvement in Psoriasis Area and Severity Index score from baseline, PASI 90, 90% or greater improvement in Psoriasis Area and Severity Index score from baseline; PASI 100, 100% improvement in Psoriasis Area and Severity Index score from baseline. Journal of the American Academy of Dermatology  , DOI: ( /j.jaad ) Copyright © 2016 American Academy of Dermatology, Inc. Terms and Conditions

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