1. Individualizing Factor Replacement Therapy for Patients With Hemophilia

3. Prophylaxis Benefits in Severe Hemophilia

5. Long-term Goals of Prophylaxis

6. Standard Factor Concentrates

7. Evaluating the Risk for Inhibitors in Standard Factor Concentrates

8. Choosing Standard Factor Concentrates

9. Overview of Available EHL Factor Concentrates

10. Overview of Investigational EHL Factor Concentrates

11. Other Novel Products

12. Novel Delivery Approaches

13. Gene Therapy

16. Should Prophylaxis Continue Into Adulthood?

17. Factor VIII Trough Level, PK, and Prophylaxis

18. PK-Directed Prophylaxis

19. Further Issues to Consider in Dosing

20. Coagulation Assays

21. Matching Dose and Regimen to Individuals

22. Hemophilia Worldwide

23. Summary

24. Abbreviations