1. Volume 136, Issue 5, Pages 1639-1650 (May 2009)
Hepatic Expression of CXC Chemokines Predicts Portal Hypertension and Survival in Patients With Alcoholic Hepatitis 
Marlene Dominguez, Rosa Miquel, Jordi Colmenero, Montserrat Moreno, Joan–Carles García–Pagán, Jaime Bosch, Vicente Arroyo, Pere Ginès, Juan Caballería, Ramón Bataller 
Gastroenterology 
Volume 136, Issue 5, Pages (May 2009)
DOI: /j.gastro
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2. Figure 1
(A–D) Identification of components of the CXC chemokine family that correlate with 90-day mortality in patients with AH. Gro-γ, ENA-78, GCP-2, and IL-8 hepatic gene expression was higher in patients who died at 90 days. *P < .05. (E) Kaplan–Meier curve showing 90-day survival according to IL-8 gene expression (fold expression respect to controls). A value of 9.33 (fold expression) was identified as the cut-off value with better sensitivity and specificity to define patients with low and high IL-8 gene expression. (F) Kaplan–Meier curve showing 90-day survival according to ENA-78 gene expression (fold-expression compared to controls). A value of 88 (fold expression) was identified as the cut-off value with better sensitivity and specificity to define patients with low and high ENA-78 gene expression.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2009 AGA Institute Terms and Conditions

3. Figure 2
(A and B) Representative photomicrographs of livers with AH stained with anti-CD15 (neutrophils) and anti-CD3 (lymphocytes), respectively (magnification, 200×). (C–H) Identification of components of CXC chemokines that correlated with the degree of neutrophil infiltration in livers with AH. The median value of 52 cells/high-power field was used as the cut-off value to define patients with low and high hepatic neutrophil infiltration. IL-8, ENA-78, Gro-γ, Gro-α, CXCR1, and CXCR2 hepatic gene expression was higher in patients who had severe neutrophil infiltration. *P < .05.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2009 AGA Institute Terms and Conditions

4. Figure 3
Identification of components of CXC chemokines that correlate with severe portal hypertension. The median value of 20 mm Hg of HVPG was used as the cut-off value to define patients with lower and higher degrees of portal hypertension. (A) Gro-γ, (B) ENA-78, and (C) IL-8 hepatic gene expression was higher in patients with more severe portal hypertension. *P < .05.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2009 AGA Institute Terms and Conditions

5. Figure 4
Representative photomicrographs of livers with AH with (A) none/mild and (B) moderate/marked staining with anti–IL-8 (magnification, 200×). (C) Kaplan–Meier curve showing 90-day survival according to IL-8 liver protein expression. Representative photomicrographs of livers with AH with (D) none/mild and (E) moderate/marked staining with anti–ENA-78 (magnification, 200×). (F) Kaplan–Meier curve showing 90-day survival according to ENA-78 liver protein expression. Patients with moderate/marked IL-8 and ENA-78 protein expression had higher 90-day mortality.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2009 AGA Institute Terms and Conditions