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SDC pipeline crystals screened

Published byMaria Luiza Canela Miranda Modified over 6 years ago

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Presentation on theme: "SDC pipeline crystals screened"— Presentation transcript:

1 SDC pipeline 2004 - 2006 2004 9579 crystals screened
301 targets screened 350 datasets collected 162 targets collected 142 targets solved by X-ray 71 targets deposited 2006 20971 647 641 311 278 248 Crystal supply Phasing Data collection Screening Tracing BL robotics Publication Annotation Quality Control Refinement PDB

2 SDC progress PSI-2 versus PSI-1
# Datasets Targets collected Targets solved Targets unsolved Targets in PDB PFAM 27 / 27 17 / 17 14 / 14 3 / 3 6 / 6 CML 35 / 35 19 / 19 18 / 18 1 / 1 16 / 16 TM 37 / 374 26 / 184 21 / 163 5 / 21 17 / 150 TM orthologs 9 / 40 7 / 24 2 / 3 Mouse 7 / 32 5 / 12 4 / 11 Mouse orthologs 2 / 76 2 / 31 2 / 25 0 / 6 1 / 22 Other 16 / 57 10 / 30 6 / 21 4 / 9 Total 133 / 641 86 / 317 69 / 273 17 / 44 54 / 247

3 SDC pipeline 2006 - 2010 Complete staffing
Well defined workflow, improve efficiency Regularly scheduled beamtime Crystal supply 6 > 3 days 9 > 3 days 14 > 7 days Phasing Data collection Screening Tracing BL robotics Overall 82 days > 60 days Publication Annotation Quality Control Refinement 53 > 47 days PDB

4 Gye Won Han Mike DiDonato Lukasz Jaroszewski

5 Scientific Advisory Board
GNF & TSRI Crystallomics Core Scott Lesley Mark Knuth Dennis Carlton Marc Deller Thomas Clayton Michael DiDonato Glen Spraggon Andreas Kreusch Daniel McMullan Heath Klock Polat Abdubek Eileen Ambing Joanna C. Hale Eric Hampton Eric Koesema Edward Nigoghossian Aprilfawn White Sanjay Agarwalla Christina Trout Ylva Elias Hope Johnson Jessica Paulsen Linda Okach Bernhard Geierstanger Julie Feuerhelm Jessica Canseco Scientific Advisory Board Sir Tom Blundell Univ. Cambridge Homme Helinga Duke University Medical Center James Naismith The Scottish Structural Proteomics facility Univ. St. Andrews James Paulson, Consortium for Functional Glycomics, The Scripps Research Institute Robert Stroud, Center for Structure of Membrane Proteins, Membrane Protein Expression Center UC San Francisco Todd Yeates, UCLA-DOE, Inst. for Genomics and Proteomics Soichi Wakatsuki, Photon Factory, KEK, Japan James Wells, Stanford /SSRL Structure Determination Core Keith Hodgson Ashley Deacon Mitchell Miller Herbert Axelrod Hsiu-Ju (Jessica) Chiu Kevin Jin Christopher Rife Qingping Xu Silvya Oommachen Henry van den Bedem Scott Talafuse Ronald Reyes Abhinav Kumar Jonathan Caruthers Chloe Zabieta Amanda Prado UCSD & Burnham Bioinformatics Core John Wooley Adam Godzik Slawomir Grzechnik Lukasz Jaroszewski Sri Krishna Subramanian Andrew Morse Tamara Astakhova Lian Duan Piotr Kozbial Naomi Cotton Dana Weekes Lukasz Slabinski Josie Alaoen TSRI NMR Core Kurt Wüthrich Reto Horst Maggie Johnson Marcius Almeida Michael Gerault Wojtek Augustyniak Pedro Serrano Bill Pedrini TSRI Administrative Core Ian Wilson Marc Elsliger Jason Kay Gye Won Han David Marciano The JCSG is supported by the NIH Protein Structure Initiative grant U54 GM from the National Institute of General Medical Sciences (

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