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Increased cyclic guanosine monophosphate levels and continuous-flow left-ventricular assist devices: Implications for gastrointestinal bleeding  Liza.

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Presentation on theme: "Increased cyclic guanosine monophosphate levels and continuous-flow left-ventricular assist devices: Implications for gastrointestinal bleeding  Liza."— Presentation transcript:

1 Increased cyclic guanosine monophosphate levels and continuous-flow left-ventricular assist devices: Implications for gastrointestinal bleeding  Liza Grosman-Rimon, PhD, Laura C. Tumiati, BSc, Avi Fuks, MD, Ira Jacobs, DrMedSci, Spencer D. Lalonde, HBSc, David Z.I. Cherney, MD, PhD, Vivek Rao, MD, PhD  The Journal of Thoracic and Cardiovascular Surgery  Volume 151, Issue 1, Pages (January 2016) DOI: /j.jtcvs Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

2 Figure 1 The top and bottom borders of the box mark the 75th and 25th percentiles, respectively; whiskers mark the 90th and 10th percentiles. A circle with a cross represents extreme outliers beyond the 90th and 10th percentiles; horizontal red line indicates the median. In patients with heart failure, CF-LVAD recipients, and healthy controls: (A) levels of BNP (pg/mL); (B) levels of cGMP (pmol/mL); and (C) levels of CRP (mg/L). BNP, B-type natriuretic peptide; CF-LVAD, continuous flow left-ventricular assist device; cGMP, cyclic guanosine monophosphate; CRP, C-reactive protein. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

3 Figure 2 A, The relationship between cGMP (pmol/mL) and BNP (pg/mL) levels in CF-LVAD recipients (B) The relationship between NO (pmol/mL) and length of continuous LVAD support. NO, Nitric oxide; LVAD, left-ventricular assist device; cGMP, cyclic guanosine monophosphate; BNP, B-type natriuretic peptide. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

4 In CF-LVAD recipients, cGMP levels were significantly correlated with the levels of BNP. While elevated cGMP levels predicted GI Bleeding events, the levels of BNP did not predict bleeding events in these patients. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

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