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Production of chemokines and proinflammatory and antiinflammatory cytokines by human alveolar macrophages activated by IgE receptors  Philippe Gosset,

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Presentation on theme: "Production of chemokines and proinflammatory and antiinflammatory cytokines by human alveolar macrophages activated by IgE receptors  Philippe Gosset,"— Presentation transcript:

1 Production of chemokines and proinflammatory and antiinflammatory cytokines by human alveolar macrophages activated by IgE receptors  Philippe Gosset, PhD, Isabelle Tillie-Leblond, MD, Séverine Oudin, MBS, Odile Parmentier, MBS, Benoit Wallaert, MD, Michel Joseph, PhD, André-Bernard Tonnel, MD  Journal of Allergy and Clinical Immunology  Volume 103, Issue 2, Pages (February 1999) DOI: /S (99)70504-X Copyright © 1999 Mosby, Inc. Terms and Conditions

2 Fig. 1 Production of proinflammatory cytokines, namely TNF (A ) and IL-1β (B ), by AMs from healthy subjects and patients with allergic asthma. Cytokine secretion was evaluated in 18-hour supernatants from AMs incubated in medium alone, in the presence of either an unrelevant mouse monoclonal IgG1 antibody (control IgG1) or a mouse monoclonal IgG1 antibody anti-CD23, and after incubation with IgE and anti-IgE. *P < .05 versus AMs from control subjects cultured in medium alone; #P < .01 versus AMs from the same group cultured in medium alone. Journal of Allergy and Clinical Immunology  , DOI: ( /S (99)70504-X) Copyright © 1999 Mosby, Inc. Terms and Conditions

3 Fig. 2 Production of chemokines, namely IL-8 (A ), MCP-1 (B ), and MIP-1α (C ), by AMs from healthy subjects and patients with allergic asthma. The secretion of chemokines was evaluated in 18-hour supernatants from AMs incubated in medium alone, in the presence of either an unrelevant mouse monoclonal IgG1 antibody (control IgG1) or a mouse monoclonal IgG1 antibody anti-CD23, and after incubation with IgE and anti-IgE. *P < .05 versus AMs from control subjects cultured in medium alone; #P < .01 versus AMs from the same group cultured in medium alone. Journal of Allergy and Clinical Immunology  , DOI: ( /S (99)70504-X) Copyright © 1999 Mosby, Inc. Terms and Conditions

4 Fig. 3 Production of antiinflammatory cytokines, namely IL-1ra (A) and IL-10 (B) , by AMs from healthy subjects and patients with allergic asthma. Secretion of IL-1ra and IL-10 was evaluated in 18-hour supernatants from AMs incubated in medium alone, in the presence of either an unrelevant mouse monoclonal IgG1 antibody (control IgG1) or a mouse monoclonal IgG1 antibody anti-CD23, and after incubation with IgE and anti-IgE. #P < .01 versus AMs from the same group cultured in medium alone. Journal of Allergy and Clinical Immunology  , DOI: ( /S (99)70504-X) Copyright © 1999 Mosby, Inc. Terms and Conditions

5 Fig. 4 Expression of mRNA encoding for TNF, IL-10, IL-8, and MCP-1 was measured by RT-PCR in AMs from control subjects (n = 6) and patients with allergic asthma (n = 6). AMs were incubated for 4 hours in medium alone, in the presence of either an unrelevant mouse monoclonal IgG1 antibody (control IgG1) or a mouse monoclonal IgG 1 antibody anti-CD23, and after incubation with IgE and anti-IgE. The expression of mRNA was quantified by densitometry, and the results were expressed as the ratio between cytokine and GAPDH mRNA (×100). *P < .05 versus AMs from the same group cultured in medium alone. Journal of Allergy and Clinical Immunology  , DOI: ( /S (99)70504-X) Copyright © 1999 Mosby, Inc. Terms and Conditions

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