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Figure 1 Imaging, histopathology, and molecular evaluation of case 1 with definite leptomeningeal angiomatosis Imaging, histopathology, and molecular evaluation.

Published byἜβέρ Ζαφειρόπουλος Modified over 5 years ago

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Presentation on theme: "Figure 1 Imaging, histopathology, and molecular evaluation of case 1 with definite leptomeningeal angiomatosis Imaging, histopathology, and molecular evaluation."— Presentation transcript:

1 Figure 1 Imaging, histopathology, and molecular evaluation of case 1 with definite leptomeningeal angiomatosis Imaging, histopathology, and molecular evaluation of case 1 with definite leptomeningeal angiomatosis (A) Precontrast T1-weighted axial MRI scan showing right temporal and occipital atrophy and right occipital cortical calcification. (B) Postcontrast T1-weighted axial MRI scan showing leptomeningeal enhancement. (C) Hematoxylin and eosin–stained image of the neocortex showing a small area of densely clustered leptomeningeal vessels. (D) Identification of the wild-type GNAQ allele in green (present in the brain and blood) by digital PCR. (E) Identification of the mutant GNAQ R183Q allele (in blue) in the brain-derived but not blood-derived DNA—rare blue dots in blood are signal from droplets containing multiple DNA templates (supplemental data, links.lww.com/NXG/A48). Droplets without DNA templates are gray. Y-axis, amplitude of fluorescent signal. WT = wild-type GNAQ probe; MUT = mutant GNAQ R183Q probe. Michael S. Hildebrand et al. Neurol Genet 2018;4:e236 Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

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