1. Sugar Makes Fat by Talking to SCAP
Wei Shao, Peter J. Espenshade 
Cancer Cell 
Volume 28, Issue 5, Pages (November 2015)
DOI: /j.ccell
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2. Figure 1 Glucose-Induced Activation of SREBP and Lipogenesis
Glucose promotes lipogenesis by (1) generating acetyl-CoA, the substrate for lipogenesis; (2) stimulating pancreatic insulin secretion, which activates SREBP-dependent lipogenic gene expression; and (3) generating UDP-GlcNAc required for SCAP N-glycosylation. Glycosylation of SCAP prevents its degradation and promotes disassociation from the ER-resident protein INSIG, resulting in SREBP activation. Abbreviations: INSIG, insulin-induced gene; UDP-GlcNAc; uridine diphosphate N-acetylglucosamine; acetyl-CoA, acetyl coenzyme A.
Cancer Cell  , DOI: ( /j.ccell )
Copyright © 2015 Elsevier Inc. Terms and Conditions