1. Steroids Overall Organization of the Lecture Series Introduction
- Structure, Nomenclature, Conformation, Configuration
Hypercholesterolemia
- Cholesterol, Anti-hyperlipidemic Agents
Male Sex Hormones
- Androgens
Female Sex Hormones
- Estrogens and Progestins
Adrenocorticoids
- Anti-inflammatory and Salt Retaining Agents
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MEDC 603 Steroids

2. Examples of Steroid-based Drugs in Use Today
Male Sex
Hormone
Female Sex
Hormone
Congested Heart
Symptoms
Anti-inflammatory
Agent
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MEDC 603 Steroids

3. Structures of Steroids
Structure and Nomenclature of the Steroid Nucleus 18
CH3 12 15 16 17 19 11 13 A B C D 1 8 9 2 14 10 3 6 7 5 4
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MEDC 603 Steroids

4. Structures of Steroids
Structure and Nomenclature of the Steroid Side-chain 21 22 20 26 27 23 24 25
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MEDC 603 Steroids

5. Configurational Isomers of Steroids
Fusion points between rings
A B
A B
trans- configuration
cis- configuration
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MEDC 603 Steroids

6. Configurational Isomers of Steroids
Fusion points between rings A B C D
3 fusion points  23 isomers = 8
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MEDC 603 Steroids

7. Configurational Isomers of Steroids
Three dimensional structure of three most common isomers
trans-trans-trans
cis-trans-trans
cis-trans-cis
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MEDC 603 Steroids

8. Nomenclature of Steroids
a- and b- configuration and numbering
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MEDC 603 Steroids

9. Nomenclature of Steroids
a- and b- configuration and numbering
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MEDC 603 Steroids

10. Biosynthesis and Metabolism of Cholesterol
CH3-C-SCoA OOC-CH2-C-CH2-C-SCoA O OH
CH3
acetyl coenzyme A hydroxy-3-methyl-glutaryl-CoA
HMG CoA
reductase
cholesterol
-OOC-CH2-C-CH2-CH2-OH OH
CH3
mevalonate
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MEDC 603 Steroids

11. Biosynthesis and Metabolism of Cholesterol
liver
various tissues
Bile Acids
(cholic acid, desoxy
cholic acid, etc.)
Hormones
(testosterone, progesterone
cortisol, estradiol, etc.)
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MEDC 603 Steroids