1. Basal Ganglia
Lec 13

3. Major Diseases of the Basal Ganglia
Parkinson’s disease
Huntington’s disease
Hemiballism
Athetosis
Dystonia
Restless Leg Syndrome
Psychiatric diseases (OCD), Tourette’s syndrome

4. IT IS :Parkinson’s Disease

5. Motor Symptoms:- The Cardinal signs of PD are :-
1- Tremor (Resting tremor).
2- Rigidity (muscle stiffness)
3- Brady Kinesia/ Akinesia.
4- Postural instability.

6. Dauer W, Przedborski S. Parkinson's disease: mechanisms and models
Dauer W, Przedborski S.. Parkinson's disease: mechanisms and models. Neuron :

7. Schapira AH, Olanow CW.. Neuroprotection in Parkinson disease: mysteries, myths, and misconceptions. JAMA Jan 21;291(3):   

8. Deep Brain Stimulation (DBS)
DBS targets areas in the brain where uncontrolled movements originate. The targeted region is inactivated, not destroyed, by an implanted electrode. The electrode is connected via a wire running beneath the skin to a stimulator and battery pack in the patient's chest.

9. Deep Brain Stimulation (DBS)