1. (p for noninferiority = 0.0004)
FIRE AND ICE
Trial design: Patients with paroxysmal atrial fibrillation were randomized to pulmonary vein isolation by cryoballoon ablation (n = 378) vs. radiofrequency current ablation (n = 384).
Results
(p for noninferiority = )
Recurrent atrial fibrillation: 34.6% of the cryoballoon ablation group vs. 35.9% of the radiofrequency current ablation group (p for noninferiority = )
Procedure time: 124 minutes with cryoablation vs. 142 minutes with radiofrequency ablation (p < )
Fluoroscopy time: 22 minutes with cryoablation vs. 17 minutes with radiofrequency ablation (p < )
35.9
34.6 %
Conclusions
Among patients with drug-refractory paroxysmal atrial fibrillation, pulmonary vein isolation by cryoballoon ablation was noninferior to radiofrequency current ablation
Radiofrequency ablation
Cryoablation
Kuck KH, et al. N Engl J Med 2016;374;