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Brian Bond, Judith Quinlan, George E. Dukes, Fermin Mearin, Ray E

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1 Irritable Bowel Syndrome: More Than Abdominal Pain and Bowel Habit Abnormalities 
Brian Bond, Judith Quinlan, George E. Dukes, Fermin Mearin, Ray E. Clouse, David H. Alpers  Clinical Gastroenterology and Hepatology  Volume 7, Issue 1, Pages (January 2009) DOI: /j.cgh Copyright © 2009 AGA Institute Terms and Conditions

2 Figure 1 Loadings plot of the first 2 components from the analysis of daily data in the first period. Each variable is represented 28 times, once for each day in the study. The abscissa represents the first component (p[1]), and the ordinate represents the second component (p[2]). Diarrhea: SoLi, lilac; Lava, green; Urge, black; Move, light blue. Constipation: Cons, blue; Push,yellow. Other Symptoms: Inco, lilac; Abdo, red; Flat, orange; Burn, light green; Pain, magenta; Symp, dark green; SymS, purple. Clinical Gastroenterology and Hepatology 2009 7, 73-79DOI: ( /j.cgh ) Copyright © 2009 AGA Institute Terms and Conditions

3 Figure 2 Scores plot of the first 2 components from the analysis of daily data in the first period. Each subject is labeled by a unique subject id number. The abscissa represents the first principal component (p[1]), and the ordinate represents the second principal component (p[2]). The central ellipse represents the Hotteling T2 95% confidence interval. Clinical Gastroenterology and Hepatology 2009 7, 73-79DOI: ( /j.cgh ) Copyright © 2009 AGA Institute Terms and Conditions

4 Figure 3 Loadings plot of the second and third components from the analysis of daily data in the first period. The labels and coloring are similar to that used in Figure 1. The abscissa represents the second principal component (p[2]), and the ordinate represents the third component (p[3]). Clinical Gastroenterology and Hepatology 2009 7, 73-79DOI: ( /j.cgh ) Copyright © 2009 AGA Institute Terms and Conditions

5 Figure 4 Scores plot of the second and third components from the analysis of daily data in the first period. The abscissa represents the second principal component (p[2]), and the ordinate represents the third component (p[3]). The central ellipse represents the Hotteling T2 95% confidence interval. Clinical Gastroenterology and Hepatology 2009 7, 73-79DOI: ( /j.cgh ) Copyright © 2009 AGA Institute Terms and Conditions

6 Figure 5 Cumulative percentage of subjects with the number of symptoms at daily, weekly, and monthly periods for period 1. Clinical Gastroenterology and Hepatology 2009 7, 73-79DOI: ( /j.cgh ) Copyright © 2009 AGA Institute Terms and Conditions

7 Figure 6 Sample of subject profiles. (A) Subject 251 with IBS and severe diarrhea; (B) Subject 999 with IBS and severe constipation; (C) Subject 916 with IBS and severe non-specific abdominal symptoms. These subjects can be identified in the right-hand part of Figure 2. Profiles of each symptom have been plotted on a contributions plot. Each bar shows the deviation of the subject from the average, in standard deviations, for the variables in the model. Clinical Gastroenterology and Hepatology 2009 7, 73-79DOI: ( /j.cgh ) Copyright © 2009 AGA Institute Terms and Conditions

8 Figure 7 Loadings plot of the first 2 components from the analysis of baseline and monthly measures in the first period. The sum of all the subject assessments for each variable is identified by the abbreviation for the variable next to the filled square (for subjects) and empty square (for physicians). The abscissa represents the first principal component (p[1]), and the ordinate represents the second component (p[2]). Clinical Gastroenterology and Hepatology 2009 7, 73-79DOI: ( /j.cgh ) Copyright © 2009 AGA Institute Terms and Conditions


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