1. Genomics Education Programme
Dr Anneke Seller: Scientific Director and Head of Programme
Cancer Validation and Reporting Workshop - June

2. HEE Genomics Education Programme
Established in 2014
Up until March 2018 are aims were to:
Post March are aims are as above plus:
Embed genomic medicine into mainstream practice
Increase capacity and capability
Support 100,000 Genomes Project
Align to NHSE Vision for Genomic Medicine
National oversight of Genomics Education
Align to Government/DH recommendations
@Genomicsedu #genomes100k

3. Resources to support the 100kGP
Identify the participant
Consent process
Sample collection & DNA extraction
Sequence annotation, validation and interpretation
Reporting of findings
100,000 Genomes Project pipeline
Eligibility Wheels: >60 at-a-glance guides across 15 medical specialties to help clinicians identify eligible participants to join the 100,000 Genomes Project. 2,700+ downloads to date.
Consent & Ethics: Short online course designed for clinicians seeking participant consent to join the 100,000 Genomes Project. 2,800+ course completions to date.
Sample Processing and DNA Extraction: Series of instructional videos produced for staff in molecular genetics and histopathology labs. 3,500+ views to date.
Tumour Assessment Tool: Education and training modules for healthcare scientists and histopathologists on accurately assessing tumour samples for genomic sequencing. (1st module live on website)
Validation of Results: Online collaboration hub launched for discussion of rare disease cases and sharing good practice. Scoping exercise underway to develop education and training resources.
Feedback of Results: Package of resources to support clinicians who receive the genomic rare disease results report, and identify elements that will inform the patient’s prognosis and treatment. (DUE 2018)
@Genomicsedu #genomes100k

4. Tumour Assessment Training Tool
First in series of four modules now published
Tumour Assessment in the Genomic Era:
Evidence for a Systematic Approach: out now
Adopting a Systematic Model: June 2018
Assessment: June 2018
(Supplementary) Intro to Tissue Pathology: (TBC) 
Aimed at histopathologists, and clinical and biomedical scientists
Built within Philips Tutor/PathXL environment to allow learners to view and assess slides up to x40 magnification at high resolution
Modules based on Royal Marsden/QUB model of tumour assessment for FFPE samples going forward for DNA extraction and genomic sequencing
Study suggests model can reduce disparity in results from up to 80% to 20% (David Gonzalez de Castro – unpublished)
@Genomicsedu #genomes100k

5. Work the GEP is doing to support the feedback of rare disease results
@Genomicsedu #genomes100k

6. Feedback of rare disease results: Short guide for clinicians
Collaboration with Genomics England and East of England NHS GMC
Crib sheet to accompany rare disease results
Providing top level headlines of what to consider for the clinical management of the patient and their family– it is not a substitute for clinical judgement/involvement of MDT
Includes ‘top tips’ from participants of the 100,000 Genomes Project
Information relates to the question: Does the individual now have a molecular diagnosis?
Yes – what to do next for the patient and the family
Uncertain – what to do next
No – what to do next
@Genomicsedu #genomes100k

7. Feedback of rare disease results: Supplementary resources to be developed
ACGS guidelines (2017) variant classification – resource for mainstream clinicians
Aim to improve knowledge NOT to become proficient
Lived experience of receiving results
Patients/participants as our ‘subject matter experts’
‘life changing answers’ – negative result will have an impact
Exploring opportunities with members of the Participant Panel
@Genomicsedu #genomes100k

8. Questions for the group
Would a similar package of resources be useful to accompany results from the cancer arm of the 100,000 Genomes Project?
If so, what information would it be helpful to include?
Any volunteers to work with us on this project?
@Genomicsedu #genomes100k

9. Additional resources developed and funded by the GEP
@Genomicsedu #genomes100k

10. A range of CPD opportunities
Tweets
Blog articles
Resources
(factsheets, guides, videos)
Short course
(hours)
Long course
(weeks)
Qualifications
A range of CPD opportunities
From formal qualifications to social media:
From ‘just in case’ education to ‘just in time’ information:
Formal learning (eg course)
Opportunistic learning (eg factsheet)
Opportunistic learning – ‘informal’ learning as defined by the GMC
Different activities that people engage in will depend on:
Learning motivation
Learning need
Learning style
@Genomicsedu #genomes100k

11. MSc in Genomic Medicine Framework
Core
Optional
Introduction to human genetics and genomics
Ethical, Legal and social issues in applied genomics 
Omics techniques and their application to genomic medicine
Counselling skills for genomics
Genomics of common and rare diseases
Economic models and human genomics
Molecular Pathology of cancer and application in diagnosis
Professional and research skills
Pharmacogenomics and stratified healthcare
Advanced bioinformatics
Application of genomics in infectious diseases
Genome-based therapeutics
 Bioinformatics, interpretation and data quality assurance in genomic analysis  
Cardiovascular genetics and genomics 
Research project / dissertation
Applied next generation sequencing
From Sept 2018:
7 Russell Group HEIs
Framework: MSc,
PGCert, PGDip, CPPD  
1239 individuals have participated  
Funding
For more information about available funding* for NHS staff visit
*Please note funding only available for staff employed in England
@Genomicsedu #genomes100k

12. Genomics in Medical Specialties
Launched short film ‘Genomics in Pathology’ as part of a new series
Features interviews with Dr Jane Moorhead, King’s College Hospital, and Prof Louise Jones, Barts Health NHS Trust
Film highlights latest developments in pathology and cancer treatment
Accompanied by info / factsheet
Receiving good engagement in first 2 weeks: 100+ shares and likes on Twitter, c100 views of full-length video and c1,700 views of short promo film
@Genomicsedu #genomes100k

13. Question for the group
What else can we do we do to support your (and your colleagues) work?
@Genomicsedu #genomes100k

14. Genomics Education Programme
And our social media…
@Genomicsedu #genomes100k