1. Inferred dynamic model of transcriptional regulatory network.
Inferred dynamic model of transcriptional regulatory network. The model, based on data presented here and data from the literature, shows active paths after the switch from low glucose to oleate at four time points (immediate, early, 5 h and late). Information flow (directed edges) is shown between stimuli (diamond nodes), genes (linear nodes with arrows), proteins (circular nodes) and network topology clusters (box nodes). Activities of nodes and influences of edges are colored red or green to represent down‐ or upregulation, respectively. Regions of the network are highlighted in color and labeled (inverted text with black background) according to the biological response they represent. It should be noted that recent data suggest that YDR215C, the ORF immediately upstream of ADR1, is unlikely to encode a protein (Fisk et al, 2006). Accordingly, intergenic region iYDR214W is annotated as a regulator of ADR1 (Macisaac et al, 2006) and ADR1 is in the AOY topology cluster in the oleate network (Supplementary Table 2). However, owing to the preliminary nature of the evidence, these interactions do not appear in the model.
Jennifer J Smith et al. Mol Syst Biol 2007;3:115
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