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A New “Spin” on Recovery after Spinal Cord Injury

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Presentation on theme: "A New “Spin” on Recovery after Spinal Cord Injury"— Presentation transcript:

1 A New “Spin” on Recovery after Spinal Cord Injury
Andrea Tedeschi, Frank Bradke  Cell  Volume 159, Issue 7, Pages (December 2014) DOI: /j.cell Copyright © 2014 Elsevier Inc. Terms and Conditions

2 Figure 1 Promoting Neuroplasticity and Recovery after Spinal Cord Injury (A) Muscle spindles are sensory organs located in skeletal muscles that receive innervation by specialized motor (efferent) and sensory (afferent) axons. Proprioceptive sensory axons originating from dorsal root ganglia (DRG) neurons spiral around the central region of the intrafusal fibers and respond to fiber stretch. The contractile regions of intrafusal fibers receive innervation by gamma motor neurons. (B) Muscle spindle feedback promotes neuroplasticity and functional recovery after incomplete spinal cord injury. Absence of muscle spindle inputs in Egr3 mutant mice results in impaired neuroplasticity and lack of recovery. Cell  , DOI: ( /j.cell ) Copyright © 2014 Elsevier Inc. Terms and Conditions

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