1. Yes No Yes Yes No No Yes No Yes No
Hypereosinophilia with end-organ damage
Yes
Treat with corticosteroids
Is emergency treatment required?
(i.e. life-threatening organ involvement) No
Treat as per idiopathic HES*
Yes
Yes
Is it LV-HES?
Is the eosinophilia reactive? No No
Treat underlying cause
Is there a primary (clonal) eosinophilia?
Yes No
Is there a confirmed molecular target?
Treat as per idiopathic HES*
Yes No
Treat with TKI or JAK2 inhibitor therapy
Treat as appropriate for a myeloid neoplasm
*Treatments include corticosteroids, trial of TKI therapy, interferon, ciclosporin, azathioprine, hydroxycarbamide. See text for details.
HES, hypereosinophilic syndrome: LV-HES, lymphocyte variant hypereosinophilic syndrome; TKI, tyrosine kinase inhibitor