1. Pathophysiology of high-risk pulmonary embolism (PE) and intracerebral haemorrhage following thrombolysis.
Pathophysiology of high-risk pulmonary embolism (PE) and intracerebral haemorrhage following thrombolysis. In intermediate-risk and high-risk PE, peripheral thrombus (1) and emboli (2) in the arterial pulmonary tree (3) may induce right ventricular dysfunction and sometimes failure (4), leading to a decreased cerebral, renal and hepatic venous return. The venous congestion (5) added to hepatic hypoxaemia, and an impaired renal clearance may affect haemostasis and PE clot sensitivity to lytics (6). Therapies associating heparin infusion and thrombolytics (7) could provoke major bleeding (8).
Paul Abraham et al. Open Heart 2018;5:e000735
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