1. Simplistic Inflammatory and Non-Inflammatory Effects of Insulin Resistance on B-Cell Function
IAPP boosts islet macrophage IL-1 in type 2 diabetes : Nature ...

2. Inflammation in IR

3. Pathogenesis and biological interventions in
T1DM- LIKE autoimmune diabetes- Insulitis
The class I MHC molecules are hyperexpressed on the β-cell surface in T1D patients making β-cells more susceptible to cytotoxic lymphocyte (CTL)-mediated destruction.
Novel diagnostic and therapeutic approaches for autoimmune diabetes — A prime time to treat insulitis as a disease
Clinical Immunology, 2014
Juha Grönholm , Michael J. Lenardo

4. Treatment IR induced Inflammation

5. Implications for Therapy
Treat Central Mechanisms IR
Treat Peripheral IR- fat, liver, muscle
Treat Inflammation
Treat Biome

6. Metabolic Derangement, and Insulin Resistance
Associated with Microbiome
Lipopolysaccharides
LPS
Fasting-induced
adipocyte factor
Pioglitazone Treats Secondary Adverse Effects of Abnormal Biome

7. Probiotic, Prebiotic and Antibiotic Treatment of Abnormal Gut Biome