Presentation is loading. Please wait.

Presentation is loading. Please wait.

Genomic Alterations in Biliary Tract Cancer Using Targeted Sequencing

Published byJosé Manuel Mora Maidana Modified over 6 years ago

Similar presentations

Presentation on theme: "Genomic Alterations in Biliary Tract Cancer Using Targeted Sequencing"— Presentation transcript:

1 Genomic Alterations in Biliary Tract Cancer Using Targeted Sequencing
Kwai Han Yoo, Nayoung K.D. Kim, Woo Il Kwon, Chung Lee, Sun Young Kim, Jiryeon Jang, Jungmi Ahn, Mihyun Kang, Hyojin Jang, Seung Tae Kim, Soomin Ahn, Kee-Taek Jang, Young Suk Park, Woong-Yang Park, Jeeyun Lee, Jin Seok Heo, Joon Oh Park  Translational Oncology  Volume 9, Issue 3, Pages (June 2016) DOI: /j.tranon Copyright © Terms and Conditions

2 Figure 1 Genomic landscape of 19 BTC patients. Hilar CCC, hilar cholangiocarcinoma; IC CCC, intrahepatic cholangiocarcinoma; dCBD, distal common bile duct cancer; GB ADC, gallbladder adenocarcinoma; GB NEC, gallbladder neuroendocrine carcinoma; AoV, ampulla of Vater; FFPE, formalin-fixed paraffin-embedded; Amp*, amplification; Del†, deletion. Translational Oncology 2016 9, DOI: ( /j.tranon ) Copyright © Terms and Conditions

3 Figure 2 (A) Immunohistochemistry staining and (B) fluorescence in situ hybridization of HER2 in a patient with ampulla of Vater cancer (case 19 in Figure 1) (400× magnification). Translational Oncology 2016 9, DOI: ( /j.tranon ) Copyright © Terms and Conditions

4 Figure 3 Immunohistochemical correlation between primary tumors and PDCs. (A) Primary cholangiocarcinoma (adenocarcinoma) (upper panel) and PDCs derived from malignant ascites (lower panel); (B) primary cholangiocarcinoma (adenocarcinoma) (upper panel) and PDCs derived from malignant pleural effusion (lower panel); (C) primary cholangiocarcinoma (adenocarcinoma) (upper panel) and PDCs derived from malignant ascites (lower panel). *Left and right sides represent immunohistochemical staining of CK7 and CK20, respectively (400× magnification). Translational Oncology 2016 9, DOI: ( /j.tranon ) Copyright © Terms and Conditions

Download ppt "Genomic Alterations in Biliary Tract Cancer Using Targeted Sequencing"

Similar presentations

Modification of ASC1 by UFM1 Is Crucial for ERα Transactivation and Breast Cancer Development Hee Min Yoo, Sung Hwan Kang, Jae Yeon Kim, Joo Eun Lee, Min.

Modification of ASC1 by UFM1 Is Crucial for ERα Transactivation and Breast Cancer Development Hee Min Yoo, Sung Hwan Kang, Jae Yeon Kim, Joo Eun Lee, Min.
Clinical Significance of IGFBP-3 Methylation in Patients with Early Stage Gastric Cancer  Seung Tae Kim, Hye-Lim Jang, Jeeyun Lee, Se Hoon Park, Young.

Clinical Significance of IGFBP-3 Methylation in Patients with Early Stage Gastric Cancer  Seung Tae Kim, Hye-Lim Jang, Jeeyun Lee, Se Hoon Park, Young.
Differences in the Expression Profiles of Excision Repair Crosscomplementation Group 1, X-Ray Repair Crosscomplementation Group 1, and βIII-Tubulin Between.

Differences in the Expression Profiles of Excision Repair Crosscomplementation Group 1, X-Ray Repair Crosscomplementation Group 1, and βIII-Tubulin Between.
Acquired C797S Mutation upon Treatment with a T790M-Specific Third-Generation EGFR Inhibitor (HM61713) in Non–Small Cell Lung Cancer  Haa-Na Song, MD,

Acquired C797S Mutation upon Treatment with a T790M-Specific Third-Generation EGFR Inhibitor (HM61713) in Non–Small Cell Lung Cancer  Haa-Na Song, MD,
Optimal pharmacologic approach to patients with hypertriglyceridemia and low high- density lipoprotein-cholesterol: Randomized comparison of fenofibrate.

Optimal pharmacologic approach to patients with hypertriglyceridemia and low high- density lipoprotein-cholesterol: Randomized comparison of fenofibrate.
Genome-Wide Analysis of DNA Methylation and the Gene Expression Change in Lung Cancer  Yong-Jae Kwon, PhD, Seog Joo Lee, MSc, Jae Soo Koh, MD, PhD, Sung.

Genome-Wide Analysis of DNA Methylation and the Gene Expression Change in Lung Cancer  Yong-Jae Kwon, PhD, Seog Joo Lee, MSc, Jae Soo Koh, MD, PhD, Sung.
Volume 108, Issue 2, Pages (February 2014)

Volume 108, Issue 2, Pages (February 2014)
MP16-14 CLINICAL IMPLICATION OF METASTASECTOMY IN METACHRONOUS METASTATIC RENAL CELL CARCINOMA IN THE ERA OF TARGETED THERAPY  Jong Won Kim, Jongsoo Lee,

MP16-14 CLINICAL IMPLICATION OF METASTASECTOMY IN METACHRONOUS METASTATIC RENAL CELL CARCINOMA IN THE ERA OF TARGETED THERAPY  Jong Won Kim, Jongsoo Lee,
Circ Cardiovasc Interv

Circ Cardiovasc Interv
Who Are Less Likely to Receive Subsequent Chemotherapy Beyond First-Line Therapy for Advanced Non-small Cell Lung Cancer?: Implications for Selection.

Who Are Less Likely to Receive Subsequent Chemotherapy Beyond First-Line Therapy for Advanced Non-small Cell Lung Cancer?: Implications for Selection.
Antitumor Effect of AZD4547 in a Fibroblast Growth Factor Receptor 2–Amplified Gastric Cancer Patient–Derived Cell Model  Jiryeon Jang, Hee Kyung Kim,

Antitumor Effect of AZD4547 in a Fibroblast Growth Factor Receptor 2–Amplified Gastric Cancer Patient–Derived Cell Model  Jiryeon Jang, Hee Kyung Kim,
Detection of ALK Gene Rearrangement in Non-small Cell Lung Cancer: A Comparison of Fluorescence In Situ Hybridization and Chromogenic In Situ Hybridization.

Detection of ALK Gene Rearrangement in Non-small Cell Lung Cancer: A Comparison of Fluorescence In Situ Hybridization and Chromogenic In Situ Hybridization.
Features of Gastric Carcinoma With Lymphoid Stroma Associated With Epstein-Barr Virus  Hyun Lim, Young Soo Park, Jeong Hoon Lee, Da Hye Son, Ji Yong Ahn,

Features of Gastric Carcinoma With Lymphoid Stroma Associated With Epstein-Barr Virus  Hyun Lim, Young Soo Park, Jeong Hoon Lee, Da Hye Son, Ji Yong Ahn,
Two Cases of Small Cell Lung Cancer Transformation from EGFR Mutant Adenocarcinoma During AZD9291 Treatment  Jun Soo Ham, MD, Seokhwi Kim, MD, Hee Kyung.

Two Cases of Small Cell Lung Cancer Transformation from EGFR Mutant Adenocarcinoma During AZD9291 Treatment  Jun Soo Ham, MD, Seokhwi Kim, MD, Hee Kyung.
A Method to Evaluate the Quality of Clinical Gene-Panel Sequencing Data for Single- Nucleotide Variant Detection  Chung Lee, Joon S. Bae, Gyu H. Ryu, Nayoung.

A Method to Evaluate the Quality of Clinical Gene-Panel Sequencing Data for Single- Nucleotide Variant Detection  Chung Lee, Joon S. Bae, Gyu H. Ryu, Nayoung.
Malignant Pleural Mesothelioma Harboring Both G719C and S768I Mutations of EGFR Successfully Treated with Afatinib  Nobukazu Agatsuma, MD  Journal of.

Malignant Pleural Mesothelioma Harboring Both G719C and S768I Mutations of EGFR Successfully Treated with Afatinib  Nobukazu Agatsuma, MD  Journal of.
Volume 154, Issue 3, Pages (February 2018)

Volume 154, Issue 3, Pages (February 2018)
Genome-Wide Analysis of DNA Methylation and the Gene Expression Change in Lung Cancer  Yong-Jae Kwon, PhD, Seog Joo Lee, MSc, Jae Soo Koh, MD, PhD, Sung.

Genome-Wide Analysis of DNA Methylation and the Gene Expression Change in Lung Cancer  Yong-Jae Kwon, PhD, Seog Joo Lee, MSc, Jae Soo Koh, MD, PhD, Sung.
Who Are Less Likely to Receive Subsequent Chemotherapy Beyond First-Line Therapy for Advanced Non-small Cell Lung Cancer?: Implications for Selection.

Who Are Less Likely to Receive Subsequent Chemotherapy Beyond First-Line Therapy for Advanced Non-small Cell Lung Cancer?: Implications for Selection.
Detection of EGFR Mutation Status in Lung Adenocarcinoma Specimens with Different Proportions of Tumor Cells Using Two Methods of Differential Sensitivity 

Detection of EGFR Mutation Status in Lung Adenocarcinoma Specimens with Different Proportions of Tumor Cells Using Two Methods of Differential Sensitivity 

Similar presentations

Ads by Google