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The Esophageal Epithelial Barrier in Health and Disease

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Presentation on theme: "The Esophageal Epithelial Barrier in Health and Disease"— Presentation transcript:

1 The Esophageal Epithelial Barrier in Health and Disease
Christopher H. Blevins, Prasad G. Iyer, Marcelo F. Vela, David A. Katzka  Clinical Gastroenterology and Hepatology  Volume 16, Issue 5, Pages (May 2018) DOI: /j.cgh Copyright © 2018 AGA Institute Terms and Conditions

2 Figure 1 Stratified squamous epithelium of the esophagus with magnification of the intercellular apical junction complex, showing the proteins involved in each of the 3 components of this complex. E-cadherin, epithelial-cadherin; ZO, zonulin. Clinical Gastroenterology and Hepatology  , DOI: ( /j.cgh ) Copyright © 2018 AGA Institute Terms and Conditions

3 Figure 2 Hematoxylin and eosin stain of esophageal mucosa showing spongiosis (dilated intercellular spaces) marked by a white halo around epithelial cells in a patient with untreated EoE (original magnification ×20). Clinical Gastroenterology and Hepatology  , DOI: ( /j.cgh ) Copyright © 2018 AGA Institute Terms and Conditions

4 Figure 3 TEM at ×4000 magnification showing cells in the suprabasal layer in the stratified squamous esophageal mucosa in a small pilot study (n = 16) of 4 different groups of patients.27 (A) Normal intercellular diameter in control subjects with a normal waist/hip ratio (noncentrally obese) and no reflux. (B–D) Dilated intercellular spaces in patients with reflux, increased waist/hip ratio, or a combination of both. Clinical Gastroenterology and Hepatology  , DOI: ( /j.cgh ) Copyright © 2018 AGA Institute Terms and Conditions

5 Figure 4 pCLE image of the esophageal mucosa after intravenous fluorescein contrast injection in a patient with no pathologic reflux (left) and pathologic reflux (right). Clinical Gastroenterology and Hepatology  , DOI: ( /j.cgh ) Copyright © 2018 AGA Institute Terms and Conditions

6 Figure 5 Endoscopically placed mucosal impedance probe (left) and a standard ambulatory combined multichannel intraluminal impedance and pH probe with several impedance sensors along the length of the esophagus (right). Clinical Gastroenterology and Hepatology  , DOI: ( /j.cgh ) Copyright © 2018 AGA Institute Terms and Conditions


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