1. Key Manufacturing Levers to Mitigate against Supply Chain Risk
Maria Crowe
Former President of Manufacturing Operations
Eli Lilly and Company
Purdue University
February 24th, 2018

2. Supply Chain Demand Fulfillment
Agenda
Background Information
Eli Lilly and Company
Sets the Stage for Affordable Manufacturing
Product Design
Creates the Production Capability
Supply Chain Design
Satisfies the Customer
Supply Chain Demand Fulfillment

3. Eli Lilly and Company

4. Process Design Sets the Stage for Affordable Manufacturing
Robust & Stable Process is critical
Dose per Day of Therapy (D.O.T)
# of Process Steps
# of Ingredients

5. Creates the Production Capability
Supply Chain Design
Procure
Single Source V Multiple Source
Scalability
Transportation & related costs
Manufacture
Specialization API / Pharma Manuf
Common Equipment Platforms
Proximity to market & other sites
Location Adv Sourcing, Capabilities, Costs
Make V Buy (CMO)
Creates the Production Capability

6. Supply Chain Demand Fulfillment
Supply Reliability needed to Make a Sale
(Key Variables)
Robust Forecasting Capability
Demand & Demand Variability
Supply Chain Reliability
Supply Chain Lead Time
Production Capacity
Criticality of Product
To Patient
To Company Profitability
Cost of Holding Inventory
Inventory Life
Satisfies the Customer

7. Closing Thoughts
Manufacturing can utilize 3 Key Levers to Mitigate against Supply Chain Risk
Key Levers
Process Design sets the stage for Affordable Manufacturing
Supply Chain Design creates the Production Capability
Supply Chain Demand Fulfillment Satisfies the Customer