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Volume 122, Issue 7, Pages (June 2002)

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1 Volume 122, Issue 7, Pages 1721-1728 (June 2002)
Frequency of the HIV-protective CC chemokine receptor 5-Δ32/Δ32 genotype is increased in hepatitis C  Rainer P. Woitas, *, Golo Ahlenstiel, *, Agathe Iwan, *, Jürgen K. Rockstroh, *, Hans H. Brackmann‡, Bernd Kupfer§, Bertfried Matz§, Ruth Offergeld‡, Tilman Sauerbruch, *, Ulrich Spengler, *  Gastroenterology  Volume 122, Issue 7, Pages (June 2002) DOI: /gast Copyright © 2002 American Gastroenterological Association Terms and Conditions

2 Fig. 1 Frequency of the CCR5-Δ32 mutation. The plots show the percentage of CCR5-Δ32 mutations in each patient and control group. The asterisk refers to a statistically significant difference between the frequency of the homozygous CCR5-Δ32 mutation in anti–HCV-seropositive patients compared with healthy controls, anti–HIV-seropositive patients, and HCV/HIV-seropositive patients (P < 0.02). Gastroenterology  , DOI: ( /gast ) Copyright © 2002 American Gastroenterological Association Terms and Conditions

3 Fig. 2 Influence of CCR 5 genotype on hepatitis C viral load. This bar and whisker plot shows the hepatitis C viral burden in anti-HCV-seropositive patients (A) and anti-HCV/HIV-seropositive patients (B) with detectable HCV viremia by PCR. The results are stratified according to the patients' CCR5 genotypes. The boxes mark the 25th, 50th (median), and 75th percentiles, respectively. The whiskers designate the 10th and 90th percentiles. The asterisk refers to a statistically significant difference between the viral loads in CCR5-Δ32 homozygotes (CCR5-Δ32/CCR5-Δ32) vs. wild-type gene homozygotes (Mann-Whitney U test, P = 0.045). #Anti-HCV/HIV-seropositive patients with CCR5Δ32 homozygosity were not observed. Gastroenterology  , DOI: ( /gast ) Copyright © 2002 American Gastroenterological Association Terms and Conditions


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