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Volume 117, Issue 1, Pages (July 1999)

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Presentation on theme: "Volume 117, Issue 1, Pages (July 1999)"— Presentation transcript:

1 Volume 117, Issue 1, Pages 154-160 (July 1999)
p53 mutations in British patients with hepatocellular carcinoma: Clustering in genetic hemochromatosis  Guy Vautier*, Adrian B. Bomford‡, Bernard C. Portmann‡, Elizabeth Metivier‡, Roger Williams‡, Stephen D. Ryder*  Gastroenterology  Volume 117, Issue 1, Pages (July 1999) DOI: /S (99) Copyright © 1999 American Gastroenterological Association Terms and Conditions

2 Fig. 1 Site of p53 mutations in 50 British patients with HCC.
Gastroenterology  , DOI: ( /S (99) ) Copyright © 1999 American Gastroenterological Association Terms and Conditions

3 Fig. 2 Site of mutation within p53 according to origin of liver disease. (A) Alcoholic liver disease; (B) hepatitis C; (C) hemochromatosis; (D) hepatitis B. The frequency of the codon 220 A to G mutation is significantly more frequent in GH-related HCCs than HCCs of other etiologies (P = , χ2 test). Gastroenterology  , DOI: ( /S (99) ) Copyright © 1999 American Gastroenterological Association Terms and Conditions

4 Fig. 2 Site of mutation within p53 according to origin of liver disease. (A) Alcoholic liver disease; (B) hepatitis C; (C) hemochromatosis; (D) hepatitis B. The frequency of the codon 220 A to G mutation is significantly more frequent in GH-related HCCs than HCCs of other etiologies (P = , χ2 test). Gastroenterology  , DOI: ( /S (99) ) Copyright © 1999 American Gastroenterological Association Terms and Conditions


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