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Molecular Cytogenetic Characterization of a Critical Region in Bands 7q35-q36 Commonly Deleted in Malignant Myeloid Disorders by Konstanze Döhner, Jill.

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Presentation on theme: "Molecular Cytogenetic Characterization of a Critical Region in Bands 7q35-q36 Commonly Deleted in Malignant Myeloid Disorders by Konstanze Döhner, Jill."— Presentation transcript:

1 Molecular Cytogenetic Characterization of a Critical Region in Bands 7q35-q36 Commonly Deleted in Malignant Myeloid Disorders by Konstanze Döhner, Jill Brown, Ute Hehmann, Claudia Hetzel, Janet Stewart, Gordon Lowther, Claudia Scholl, Stefan Fröhling, Antonio Cuneo, Lap C. Tsui, Peter Lichter, Stephen W. Scherer, and Hartmut Döhner Blood Volume 92(11): December 1, 1998 ©1998 by American Society of Hematology

2 Mapping of deletions and a translocation involving chromosome bands 7q31-qter in 13 myeloid leukemias by FISH. HSC7E-YACs are from the chromosome 7–specific YAC library17 and the C_row_plate_ column YACs are from the CEPH-Généthon collection.21 Clones HSC7E... Mapping of deletions and a translocation involving chromosome bands 7q31-qter in 13 myeloid leukemias by FISH. HSC7E-YACs are from the chromosome 7–specific YAC library17 and the C_row_plate_ column YACs are from the CEPH-Généthon collection.21 Clones HSC7E248 to HSC7E113 recognize a contiguous genomic fragment in chromosome bands 7q35-q36. del, deletion (only one fluorescence signal); t, translocation breakpoint; di, disomy (two fluorescence signals indicating retention of both alleles); empty boxes, not done; light gray boxes, extent of the deletion; dark gray boxes, commonly deleted segment. Konstanze Döhner et al. Blood 1998;92: ©1998 by American Society of Hematology

3 Deletions or translocations involving chromosome bands 7q31-qter in 13 patients with MDS, AML, and t-AML identified by chromosome banding analysis. Deletions or translocations involving chromosome bands 7q31-qter in 13 patients with MDS, AML, and t-AML identified by chromosome banding analysis. The commonly deleted segment is delineated by the grey area. Line, deletion; point, translocation breakpoint; *, monosomy 7 within a complex karyotype. Konstanze Döhner et al. Blood 1998;92: ©1998 by American Society of Hematology


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