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Spotlight on Immuno-Oncology in Melanoma
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Introduction
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Emerging Agents Epacadostat
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Emerging Agents (cont) Epacadostat
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Emerging Agents OX40
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Emerging Agents (cont) OX40 Antibody
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Emerging Agents 4-1BB
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Emerging Agents 4-1BB Antibody
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Emerging Agents LAG-3
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Practical Implications of These Emerging Agents
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Pembrolizumab Survival Updates KEYNOTE-001
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Pembrolizumab Survival Updates KEYNOTE-006
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Notes on Stopping Therapy
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Combination Nivolumab/Ipilimumab Survival Updates CheckMate-067
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Upfront Treatment
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Combination Nivolumab/Ipilimumab Survival Updates CheckMate-069
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Are Some Patients Cured with Immunotherapy?
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Treating Patients Who Had Autoimmune Disorders or Preexisting irAEs
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Treating Patients Who Had Autoimmune Disorders or Preexisting irAEs (cont)
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Treating Brain Metastases
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Thoughts on Treating Brain Metastases
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Sequencing Therapy
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irAEs and Potential Treatment Benefit
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Discontinuing Treatment Due to AEs
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AEs and Treatment Benefit
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Practical Applications
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Patients With Wild-Type Disease That Progresses With Immunotherapy
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A Look to the Future
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Concluding Remarks
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Abbreviations
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Abbreviations (cont)
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