1. Volume 151, Issue 2, Pages 351-363.e28 (August 2016)
Four Susceptibility Loci for Gallstone Disease Identified in a Meta-analysis of Genome- Wide Association Studies 
Amit D. Joshi, Charlotte Andersson, Stephan Buch, Stefan Stender, Raymond Noordam, Lu-Chen Weng, Peter E. Weeke, Paul L. Auer, Bernhard Boehm, Constance Chen, Hyon Choi, Gary Curhan, Joshua C. Denny, Immaculata De Vivo, John D. Eicher, David Ellinghaus, Aaron R. Folsom, Charles Fuchs, Manish Gala, Jeffrey Haessler, Albert Hofman, Frank Hu, David J. Hunter, Harry L.A. Janssen, Jae H. Kang, Charles Kooperberg, Peter Kraft, Wolfgang Kratzer, Wolfgang Lieb, Pamela L. Lutsey, Sarwa Darwish Murad, Børge G. Nordestgaard, Louis R. Pasquale, Alex P. Reiner, Paul M. Ridker, Eric Rimm, Lynda M. Rose, Christian M. Shaffer, Clemens Schafmayer, Rulla M. Tamimi, André G. Uitterlinden, Uwe Völker, Henry Völzke, Yoshiyuki Wakabayashi, Janey L. Wiggs, Jun Zhu, Dan M. Roden, Bruno H. Stricker, Weihong Tang, Alexander Teumer, Jochen Hampe, Anne Tybjærg-Hansen, Daniel I. Chasman, Andrew T. Chan, Andrew D. Johnson 
Gastroenterology 
Volume 151, Issue 2, Pages e28 (August 2016)
DOI: /j.gastro
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2. Figure 1
Manhattan plot of the results of genome-wide meta-analysis of gallstone disease in 10 studies. The plot shows –log10-transformed P values for all SNPs. The red horizontal line represents a P value of 5 × The blue horizontal line represents a P value of 1 × 10-5.
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3. Figure 2
Forest plots of meta-analyses of genome-wide significant SNPs in each of the discovery and replication data sets. (A) Fixed-effects meta-analysis: rs (B) Random-effects meta-analysis: rs (C) Fixed-effects meta-analysis: rs (D) Fixed-effects meta-analysis: rs (E) Random-effects meta-analysis: rs (F) Fixed-effects meta-analysis: rs
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4. Figure 3
The possible role of novel susceptibility loci in gallstone formation.
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5. Supplementary Figure 1
Flow chart of study cohorts and methods in the discovery and replication stages. GCTA, Genome-wide complex trait analysis; LD, linkage disequilibrium.
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6. Supplementary Figure 2
Quantile-Quantile plot of gallstone disease GWAS meta-analysis.
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7. Supplementary Figure 3
Regional association plots for discovered loci in GWAS meta-analysis. (A) ABCG8 locus, (B) CYP7A1 locus, (C) GCKR locus, (D) TM4SF4 locus, and (E) SULT2A1 locus.
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8. Supplementary Figure 4
Receiver operator characteristic plots in replication studies. (A) Kiel study (total), (B) women in the Kiel study, (C) men in the Kiel study, (D) NHS replication study, and (E) HPFS replication study.
Gastroenterology  , e28DOI: ( /j.gastro )
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9. Supplementary Figure 5
RNA sequencing results from gallbladder and liver from chronic gallstones case and normal gallbladders. Comparison of reads per kilobase of transcript per million (RPKM) values for expressed genes in chronic gallstone gallbladder vs chronic gallstone liver (left panel) and chronic gallstone gallbladder vs normal (nongallstones) gallbladder. The point corresponding to TM4SF4 expression is indicated. The following genes were excluded from the plots because of their high RPKM values: MTRNR2L8, ALB, and APOA2.
Gastroenterology  , e28DOI: ( /j.gastro )
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