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Inflammatory Markers Are Associated With Risk of Colorectal Cancer and Chemopreventive Response to Anti-Inflammatory Drugs  Andrew T. Chan, Shuji Ogino,

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Presentation on theme: "Inflammatory Markers Are Associated With Risk of Colorectal Cancer and Chemopreventive Response to Anti-Inflammatory Drugs  Andrew T. Chan, Shuji Ogino,"— Presentation transcript:

1 Inflammatory Markers Are Associated With Risk of Colorectal Cancer and Chemopreventive Response to Anti-Inflammatory Drugs  Andrew T. Chan, Shuji Ogino, Edward L. Giovannucci, Charles S. Fuchs  Gastroenterology  Volume 140, Issue 3, Pages e2 (March 2011) DOI: /j.gastro Copyright © 2011 AGA Institute Terms and Conditions

2 Figure 1 Restricted cubic spline plot for sTNFR-2 and risk of colorectal cancer. RR of colorectal cancer is plotted according to plasma sTNFR-2 level (pg/mL). Hatched lines represent 95% CIs. Spline was adjusted for the same factors as the multivariate model in Table 3. A test for overall significance of the curve was statistically significant (P = .02). Gastroenterology  , e2DOI: ( /j.gastro ) Copyright © 2011 AGA Institute Terms and Conditions

3 Figure 2 Restricted cubic spline plot for CRP and risk of colorectal cancer. RR of colorectal cancer is plotted according to plasma CRP level (mg/L). Hatched lines represent 95% CIs. Spline was adjusted for the same factors as the multivariate model in Table 3. A test for overall significance of the curve was nonsignificant (P = .32). Gastroenterology  , e2DOI: ( /j.gastro ) Copyright © 2011 AGA Institute Terms and Conditions

4 Figure 3 Restricted cubic spline plot for IL-6 and risk of colorectal cancer. RR of colorectal cancer is plotted according to plasma IL-6 level (pg/mL). Hatched lines represent 95% CIs. Spline was adjusted for the same factors as the multivariate model in Table 3. A test for overall significance of the curve was nonsignificant (P = .49). Gastroenterology  , e2DOI: ( /j.gastro ) Copyright © 2011 AGA Institute Terms and Conditions

5 Supplementary Figure s1
Restricted cubic spline plot for CRP and risk of colorectal cancer. RR of colorectal cancer is plotted according to plasma CRP level (mg/L). Hatched lines represent 95% CIs. Spline was adjusted for the same factors as the multivariate model in Table 3 with the exception of current use of postmenopausal hormones. A test for overall significance of the curve was nonsignificant (P = .15). Gastroenterology  , e2DOI: ( /j.gastro ) Copyright © 2011 AGA Institute Terms and Conditions

6 Supplementary Figure s2
Restricted cubic spline plot for CRP and risk of colorectal cancer among women who currently used postmenopausal hormones. RR of colorectal cancer is plotted according to plasma CRP level (mg/L). Hatched lines represent 95% CIs. Spline was adjusted for the same factors as the multivariate model in Table 3 with the exception of current use of postmenopausal hormones. A test for overall significance of the curve was nonsignificant (P = .75). Gastroenterology  , e2DOI: ( /j.gastro ) Copyright © 2011 AGA Institute Terms and Conditions

7 Supplementary Figure s3
Restricted cubic spline plot for CRP and risk of colorectal cancer among women who did not currently use postmenopausal hormones. RR of colorectal cancer is plotted according to plasma CRP level (mg/L). Hatched lines represent 95% CIs. Spline was adjusted for the same factors as the multivariate model in Table 3 with the exception of current use of postmenopausal hormones. A test for overall significance of the curve was nonsignificant (P = .44). Gastroenterology  , e2DOI: ( /j.gastro ) Copyright © 2011 AGA Institute Terms and Conditions


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