1. Epidemiology 1.
Update of Anderson et al, J Clin Onc 2010

2. Epidemiology 2.
Update of Anderson et al, J Clin Onc 2010

3. DES and BPA BPA synthesized 19th Century, tested 1935, EC Dodds
DES synthesized 1938 by Dodd’s group

4. Low Concentrations have Big Effects, e.g. Sidenafil
100 mg dose
Mol Wt 666.7
25 mg effective for 60% of men

5. Random Peri-areolar Fine Needle Aspiration

6. Spherical Growth of HRBECs High-Risk donor Breast Epithelial Cells
Matrigel
Basal alpha-6 integrin - BLUE
Nuclei - Red
ER-alpha and ER-beta

7. Mammalian Target of Rapamycin

8. mTOR Proteins

9. Research Plan

10. Help from the Counterargument
Canned Foods
At Meals
N=20
BPA not in all
Teeguarden et al
Toxicological
Science, 2011