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Small but Mighty: Selected Commensal Bacterial Species Determine the Effectiveness of Anti-cancer Immunotherapies  Jose R. Conejo-Garcia, Melanie R. Rutkowski 

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Presentation on theme: "Small but Mighty: Selected Commensal Bacterial Species Determine the Effectiveness of Anti-cancer Immunotherapies  Jose R. Conejo-Garcia, Melanie R. Rutkowski "— Presentation transcript:

1 Small but Mighty: Selected Commensal Bacterial Species Determine the Effectiveness of Anti-cancer Immunotherapies  Jose R. Conejo-Garcia, Melanie R. Rutkowski  Immunity  Volume 43, Issue 6, Pages (December 2015) DOI: /j.immuni Copyright © 2015 Elsevier Inc. Terms and Conditions

2 Figure 1 Commensal Microbiota Enhance Therapeutic Response to Checkpoint Blockade Anti-CTLA-4 blockade is most efficacious in the presence of B. fragilis, whose cell-wall peptidoglycans activate dendritic cells to produce IL-12, enhancing Th1 cell responses and boosting endogenous anti-tumor immunity. Anti-PD-L1 therapy is enhanced through the addition of Bifidobacterium, resulting in activated DCs and enhanced anti-tumor immune responses. Immunity  , DOI: ( /j.immuni ) Copyright © 2015 Elsevier Inc. Terms and Conditions

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