1. Genomics, Proteomics & Bioinformatics
ABS-932
Introductory Lecture
Powerpoint Templates

2. Why was this course proposed?
Genomics and Proteomics are the study of genome and proteome structure and function, respectively.
These are the new and exciting areas which has recently witnessed many conceptual and technical advances.
This information is vital to our day-to-day living in this century.

3. Course Description
The main purpose of this course is to introduce concepts of human genomics and proteomics that can also be applied to microbial, plant and animal genomes/ proteomes.
The topics covered are:
Introduction to genomics/proteomics
Genomes annotation
Overview of genomics/proteomics projects
Transcriptomics
Metabolomics
Protein structure/function and Insilico Prediction
Homology modeling
Data mining
Applications of bioinformatics

4. Essential Details Credits: 3 Time: Monday and Friday 09.30 -11.00 hrs
Place: Classroom 307

5. Grades Course point distribution Class presentations/assignments 10%
Quizzes %
OHT % (2 OHTs)
End Term Exam 50%

6. keep your cell phones on silent mode or put them off.
RULES
Plan to arrive to class on time and to stay for the entire class period (or until dismissed).
NO will be allowed to enter/leave while class is in session
Talking and other disruptive behaviors are not permitted while class is in session.
Pens and pencils are distracting.
NO tapping, clicking, flipping and rolling.
keep your cell phones on silent mode or put them off.

7. What is the simplest definition of genomics?
What is the genome?
How many types of genomes are there in this world?

8. Why should we study genomes?
Each and everyone is a unique creation!
Life’s little book of instructions
DNA blue print of life!
Human body has 1013 cells and each cell has 6 billion base pairs (A, C, G, T)
A hidden language/code determines which proteins should be made and when
This language is common to all organisms

9. What can genome sequence tell us?
Everything about the organism's life
Its developmental program
Disease resistance or susceptibility
History

10. How will we change in this century because of the Genomics?
You will control the destiny of this planet
Big changes in our own life
Biotechnology: more products
GMOs: More food-More problems?
Our society will not be the same!
Individualized medicine
Gene therapy
Immortality? Disease free life?

11. What genomics has to do with me?
Wild type
What genomics has to do with me?

13. Why horse is a horse and duck is a duck?
It is in their genes!
DNA structure was discovered in 1953
DNA replicates by making a copy of itself and passes to next generation of cells or organisms
Purity of lineages maintained
Biotechnology: fish genes in plants

14. Origin of terminology
The term genome was used by German botanist Hans Winker in 1920
Collection of genes in haploid set of chromosomes
Now it encompasses all DNA in a cell
In 1986 mouse geneticist Thomas Roderick used Genomics for “mapping, sequencing and characterizing genomes”
New terms: Functional genomics, transcriptomics, proteomics, metabolomics, phenomics (Omics)

15. Origin of Genomics Human Genome Project
Goal: sequence 3 billion base pairs
High-quality sequence (<1 error per 10 K bases) ACGT
Immensity of task required new technologies
Automated sequencing
Decision to sequence other genomes: yeast and bacteria
Beginnings of comparative genomics 15

16. Technical foundations of genomics
Log MW
Distance .
Molecular biology: recombinant-DNA technology
DNA sequencing
Library construction
PCR amplification
Hybridization techniques 16

17. Genomics relies on high-throughput technologies
200 Automated sequencers
Fluorescent dyes
Robotics
Microarray spotters
Colony pickers
High-throughput genetics 17

18. Bioinformatics: computational analysis of genomics data
Uses computational approaches to solve genomics problems
Sequence analysis
Gene prediction
Modeling of biological processes/ network 18