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C-reactive protein in peripheral arterial disease: Relation to severity of the disease and to future cardiovascular events  Tryfon Vainas, MD, Frank R.M.

Published byἉλκυόνη Ρέντης Modified over 6 years ago

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Presentation on theme: "C-reactive protein in peripheral arterial disease: Relation to severity of the disease and to future cardiovascular events  Tryfon Vainas, MD, Frank R.M."— Presentation transcript:

1 C-reactive protein in peripheral arterial disease: Relation to severity of the disease and to future cardiovascular events  Tryfon Vainas, MD, Frank R.M. Stassen, PhD, Rick de Graaf, MD, Eric L.L. Twiss, MD, Selma B. Herngreen, BSc, Rob J. Th.J. Welten, MD, PhD, Luc H.J.M. van den Akker, MD, Marja P. van Dieijen-Visser, PhD, Cathrien A. Bruggeman, PhD, Peter J.E.H.M. Kitslaar, MD, PhD  Journal of Vascular Surgery  Volume 42, Issue 2, Pages (August 2005) DOI: /j.jvs Copyright © 2005 The Society for Vascular Surgery Terms and Conditions

2 Fig 1 a, Relationship between ankle-brachial pressure index (ABPI; at inclusion and at 12 months) and serum highly sensitive C-reactive protein (hsCRP) at inclusion. The average ABPI at inclusion decreased from the low-CRP group to the high-CRP group (analysis of variance [ANOVA]; Ptrend = .001). b, The average ABPI at 12 months’ follow-up also decreased from high to low baseline serum hsCRP (ANOVA; Ptrend = .001). CI, Confidence interval. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2005 The Society for Vascular Surgery Terms and Conditions

3 Fig 2 Difference in freedom from the combined end point death and/or any vascular event (coronary, cerebral, or peripheral) among patients with low vs intermediate vs high C-reactive protein (CRP; log-rank statistics; P = .036). This association persisted after correction for conventional cardiovascular risk factors and clinical extent of peripheral arterial disease (Cox proportional hazards model; P = .003). Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2005 The Society for Vascular Surgery Terms and Conditions

4 Fig 3 Representative gel showing C-reactive protein (CRP) messenger RNA in femoral atherosclerotic plaque from a patient with peripheral arterial disease. Lane 1 contains a marker for size (SmartLadder; Eurogentec Seraing, Belgium). Lane 2 has been loaded with CRP amplification product from femoral plaque. Lane 3 has been loaded with femoral plaque CRP amplification product without prior transcription of RNA into complementary DNA (-RT), demonstrating the specific amplification of RNA instead of genomic DNA. Lane 4 was loaded with cyclophilin polymerase chain reaction product from femoral plaque, and lane 5 was loaded with water. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2005 The Society for Vascular Surgery Terms and Conditions

5 Fig 4 Immunohistochemical detection of C-reactive protein (CRP) in femoral atherosclerotic plaques and apparently healthy brachial artery. CRP was abundantly present in femoral atherosclerotic plaque (A) and almost completely absent in healthy tissue (B). CRP immunostaining (C) colocalized with T cells (D), smooth muscle cells (E), and macrophages (F) in serial tissue sections of femoral atherosclerotic plaques. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2005 The Society for Vascular Surgery Terms and Conditions

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