1. Professor Martin Tobin Leicester Precision Medicine Institute
LPMI general information: Tel:
Leicester’s Research Live – celebrating our success

2. LPMI Team Martin Tobin, Director - martin.tobin@leicester.ac.uk
Jacqui Shaw, Scientific Director -
Mike Sullivan, Commercial Director (starting May 2018)
Ruth Barber, Operations Manager -
Riddhi Shukla, Business Development Manager –
Carl Edwards, Business Development and Technology Transfer Manager
Rebecca Ritchie, Administrator -
LPMI general information: Tel:

3. Leicester Precision Medicine Institute
Research excellence
Hospital Trust
Industry collaboration
Population
Discovery
Evaluation
Implementation

4. Flagship projects
Mesothelioma Stratified Therapy (MiST): a multi-arm parallel phase II umbrella trial to evaluate novel targeted therapy in malignant pleural mesothelioma (Professor Dean Fennell)
MRC Molecular Pathology Node in Breathomics (EMBER, Professor Chris Brightling)
UK Biobank study on Biological Ageing (Professor Sir Nilesh Samani)
(Professor Jacqui Shaw) Cancer diagnostics utilising circulating free DNA
Precision Medicine Cohorts (e.g. GenVasc, EXCEED, COPD cohorts)

5. Am I doing precision medicine?
The LPMI definition of Precision Medicine “right drug/treatment, right patient, right time” refers to:
The tailoring or matching of healthcare interventions to particular characteristics of patients.
Targeting interventions at those most likely to benefit.
The classification of individuals into subpopulations that differ in their disease susceptibility, prognosis, or response to individual treatments or care pathways.
If your research involves either tailoring treatments to subpopulations or identifying those most likely to benefit from existing treatments, then you are probably doing precision medicine research.

6. Benefits of engagement with LPMI
Profile of your research
Support for strategic funding applications & developing industry partnerships
PhD studentships
Fellowships (supplementing WTISSF)
Capacity-building funding
Events
Support for sandpit events

7. LMPI support for PhD studentships for Autumn 2018
Precision Medicine projects are a priority area for College of Life Sciences funded studentships:
LPMI/BRC priority studentships: 1 BRC Precision Medicine theme, 2 projects BRC Respiratory theme, 1 BRC Lifestyle theme, 2 BRC Cardiovascular theme
LMPI/Leicester Cancer Research Centre: 2 projects in Cancer precision medicine
LPMI/Informatics: studentship(s) for precision medicine health data research starting 2018 or 2019

8. Wellcome Trust ISSF fellows
Claire Lawson: cardiovascular risk factor trends and aetiological mechanisms in BME groups leading to Heart Failure.
Ranjit Arnold: role of CMR perfusion imaging in diagnosing and risk stratifying patients with suspected coronary disease.
Joshua Vande Hey: air quality and health, environmental resources for cohort studies.
Chiara Batini: genetic architecture of smoking behaviour in individuals of European, African and Asian ancestries using UK Biobank data.
Plus – two Health Data Research UK fellows, Chiara Batini and Tim Beck

9. LMPI Capacity Building Call 2017-18 funded projects
Cardiovascular magnetic resonance to individualise management in patients with suspected non-ST elevation acute coronary syndromes - Ranjit Arnold
Lifestyle and trimethylamine N-oxide: Unravelling the potential for personalised therapy - Dr Thomas Yates, Prof Toru Suzuki, Prof Don Jones & Prof Gerry McCann
Haematological malignancy panel based sequencing for clinical translation - Dr Caroline Cowley, Prof Jacqui Shaw, Prof Catrin Pritchard, Prof Martin Dyer. In collaboration with Dr Linda Barton, Consultant Haematologist & Lara Cresswell FRCPath, Clinical Lead for Molecular Diagnostics, UHL.
A Precision Medicine Cohort goes Multi-ethnic: enhancing medicines discovery in South Asians using EXCEED - Dr Catherine John, Dr Nicola Reeve, Dr Chiara Batini & Prof. Louise Wain
plus two partially funded projects
Total value of funded projects £148,000

10. LMPI Call 2018…coming soon……
Call Opening: Early May 2018
Submission Deadline: Early June 2018
Project Decision Meeting: Late June 2018
Project start date: 1st August 2018
Project end date: 31st July 2019
More information about call priority areas and confirmation of dates will be available shortly…….
To contact LPMI please drop an to

11. Updates Successful annual review 2017-18 successes so far include:
research awards £21.7m in 2016/17
growth in industry partnerships
successes so far include:
new industry partnerships
Confidence in Concept, Proximity to Discovery Awards (MRC)
Midlands Health Data Research-UK bid
Plans:
LPMI Executive Committee developing Roadmap
Accelerate ethnic health research
Develop strategic industry partnerships

12. Questions

13. Leicester Precision Medicine Institute
Research excellence
Hospital Trust
Industry collaboration
Population
Discovery
Evaluation
Implementation

14. Strategy
Develop capability in:
Multimorbidity
Ethnic Health Research
Microbial disease, including TB
Acute Care & Emergency Medicine
Med Tech platform
NIHR Clinical Research Facility
Renal disease
Sustainable growth in:
Respiratory
Cardiovascular
Diabetes/Lifestyle and Exercise
Oncology
BRC
ECMC
CTUs
EMBER
inter-disciplinary research, cross-cutting expertise and technology
Genomics & Phenomics
Epidemiology, Analytics, Informatics
Drug and diagnostic discovery
Health care systems

15. Studying populations at scale
EXCEED (10,000)
COPD
Asthma
GenVasc
(23,000)
Coronary disease
GRAPHIC (2,200)
Renal disease
Testbeds:
pharmacogenetics
Clinical Trials Unit
NIHR Clinical Research Facility
UK Biobank
Genomics England
International genomics consortia

16. Life Sciences Innovation
Industry/NHS/University Collaboration:
Reduce the Peaks and fill the Gap
Valley of
Death
Dale
of Despair
Basic Research
Target Validation
PoC
Clinical Practice & Adoption
Medical
Development
Efficacy Evaluation
Translational Requirements from Concept to Commercialisation
Capacity, Resource and Investment
TRL1
TRL10
Improved Validation
Improved Evidence
Improved Implementation