1. Enteral absorption and haemodynamic response of clonidine in infants post-cardiac surgery 
S. Arenas-Lopez, H. Mulla, S. Manna, A. Durward, I.A. Murdoch, S.M. Tibby 
British Journal of Anaesthesia 
Volume 113, Issue 6, Pages (December 2014)
DOI: /bja/aeu258
Copyright © 2014 The Author(s) Terms and Conditions

2. Fig 1
Enteral absorption profiles for all patients. The dashed horizontal line represents a plasma concentration of 0.3 ng ml−1, which is the desired minimum therapeutic concentration at which sedative effects are seen.
British Journal of Anaesthesia  , DOI: ( /bja/aeu258)
Copyright © 2014 The Author(s) Terms and Conditions

3. Fig 2
Relationship between time to maximum plasma concentration of clonidine (Tmax) and cumulative morphine dose. An interaction is seen with the use of the phosphodiesterase 3 inhibitor, milrinone. Regression lines are shown with shaded areas representing 95% confidence intervals.
British Journal of Anaesthesia  , DOI: ( /bja/aeu258)
Copyright © 2014 The Author(s) Terms and Conditions

4. Fig 3
Haemodynamic effects after clonidine administration. CVP, central venous pressure; LAP, left atrial pressure; AP, arterial pressure. Symbols represent mean values; error bars are sem.
British Journal of Anaesthesia  , DOI: ( /bja/aeu258)
Copyright © 2014 The Author(s) Terms and Conditions

5. Fig 4
Prediction-corrected visual predictive check of model performance based on n=1000 replicates. The figure utilizes combined data from the current and previous studies.14 See Supplementary material for further explanation.
British Journal of Anaesthesia  , DOI: ( /bja/aeu258)
Copyright © 2014 The Author(s) Terms and Conditions

6. Fig 5
Comparison of simulated plasma clonidine concentrations vs time for a 1-yr-old infant after a single dose of 3 μg kg−1 clonidine using absorption profiles derived from our and Larsson and colleagues'13 studies.
British Journal of Anaesthesia  , DOI: ( /bja/aeu258)
Copyright © 2014 The Author(s) Terms and Conditions