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The effects of i.v. fentanyl administration on the minimum alveolar concentration of isoflurane in horses  Thomasy S.M. , Steffey E.P. , Mama K.R. , Solano.

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Presentation on theme: "The effects of i.v. fentanyl administration on the minimum alveolar concentration of isoflurane in horses  Thomasy S.M. , Steffey E.P. , Mama K.R. , Solano."— Presentation transcript:

1 The effects of i.v. fentanyl administration on the minimum alveolar concentration of isoflurane in horses  Thomasy S.M. , Steffey E.P. , Mama K.R. , Solano A , Stanley S.D.   British Journal of Anaesthesia  Volume 97, Issue 2, Pages (August 2006) DOI: /bja/ael116 Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

2 Fig 1 Mean (+sd) plasma fentanyl concentration vs time after a loading dose administered over 12 min, then a CRI to target three different fentanyl concentrations in eight horses (n=4–6 at each data point). British Journal of Anaesthesia  , DOI: ( /bja/ael116) Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

3 Fig 2 Isoflurane MAC at different plasma fentanyl concentrations in eight horses. British Journal of Anaesthesia  , DOI: ( /bja/ael116) Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

4 Fig 3 Percentage reduction in isoflurane MAC [mean (sd)] at three different plasma fentanyl concentrations in eight horses. *P<0.05 from baseline. British Journal of Anaesthesia  , DOI: ( /bja/ael116) Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

5 Fig 4 Mean (+sd) HR (a) and MAP (b) in eight isoflurane-anaesthetized horses immediately before and after noxious stimulation at fentanyl concentrations (FC) of 0, 0.72, 8.43 and ng ml−1. aP<0.05 from 0 FC. bP<0.05 from 0.72 FC. cP<0.05 from 8.43 FC. *P<0.05 from pre-noxious stimulation. British Journal of Anaesthesia  , DOI: ( /bja/ael116) Copyright © 2006 British Journal of Anaesthesia Terms and Conditions


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