1. What does this protein make up or do?
Chapter 21: Chromosome 21
DNA Sequence
Chromosome
290,579bp
Name of Protein 21
Name of Gene
Amyloid beta (A4) precursor protein
APP
transcription
Amino acid sequence
mRNA
305 aa
translation
Cytoplasm
A Cell
Nucleus
What does this protein make up or do?
encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides.
Condition/Disease
Alzheimer disease

2. Description of Alzheimer disease
Symptoms and characteristics
Alzheimer’s is a progressive mental deterioration that can occur in middle or old age, due to generalized degeneration of the brain.
Memory loss.
The disease tends to get worse gradually. It usually starts with mild memory loss. It progresses to severe mental and functional problems and eventual death.
Challenges in planning or solving problems

3. Description of Alzheimer’s (cont.)
Who is affected? Anyone, but the following have a higher risk:
Primarily affects individuals over age 65
Outlook or quality of life
They have a difficult time remembering things.
Severe brain damage.
They eventually become completely dependent on others for care
Researcher: MM

4. References
NCBI. APP amyloid beta (A4) precursor protein [ Homo sapiens (human) [online] [cited March 3]. Available at URL:
Department of Health. Alzheimer's Disease Frequently Asked Questions [online] [cited March 3]. Available at URL:
Alzheimer’s Association. 10 Early Signs and Symptoms of Alzheimer's [online] [cited March 3]. Available at URL: