1. Essentials of Anatomy & Physiology
Fifth edition
Seeley • Stephens • Tate
Chapter 4
Tissue Repair
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2. Fig. 4.5h

3. Fig. 4.6c

4. Fig. 4.7

5. Inflammation
The function of the inflammatory response is to isolate and destroy harmful agents.
The inflammatory response produces five symptoms:
Redness
Heat
Swelling
Pain (ouch!!)
Disturbance of Function

6. Mediators of Inflammation
Chemical substances that are released or activated in the injured tissues.
Histamine (released by mast cells)
Kinins
Prostaglandins
Leukotrienes
Functions: Dilation of blood vessels, Edema, “Walling of the injury w/fibrin”,
Neutrophils move in to eat bacteria: fights infection
Macrophages eat dead tissue debris
Neutrophils + dead stuff = Pus

7. Tissue Repair Substitution of viable cells for dead cells
Regeneration = new cells are same type & normal function is usually restored
Replacement = new type of tissue develops = scar & some loss of function.
1) Fresh wound cuts through the epithelium & underlying connective tissue
2) After about 1 week, a scab is present and new E.T. is growing into the wound.
3) After about 2 weeks, the E.T. has completely grown into the wound & fibroblasts have formed granulation tissue
4) After about 1 month, the wound is completely closed & the granulation tissue is replaced w/new C.T.P.