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The functional activity of basophil granulocytes is modulated by acute mental stress and sympathetic activation in vivo and in vitro  Ulrike Raap, MD,

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Presentation on theme: "The functional activity of basophil granulocytes is modulated by acute mental stress and sympathetic activation in vivo and in vitro  Ulrike Raap, MD,"— Presentation transcript:

1 The functional activity of basophil granulocytes is modulated by acute mental stress and sympathetic activation in vivo and in vitro  Ulrike Raap, MD, Gerhard Schmid-Ott, MD, Manuela Bruder, Katja Wichmann, MD, Alexander Kapp, MD, Thomas Werfel, MD  Journal of Allergy and Clinical Immunology  Volume 122, Issue 6, Pages (December 2008) DOI: /j.jaci Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 A and B, CD63 expression of basophils at baseline (B) compared with levels at stress (S) and follow-up (F) in unstimulated (A) and fMLP-stimulated (B) basophils (n = 15). ∗P < .05, ∗∗P < .01, and ∗∗∗P < Columns represent means ± SEMs. C, CD63 expression in fMLP-stimulated basophils of 4 donors who did not participate in the TSST coincubated with 1 different serum in each experiment of 4 individuals who did undergo the TSST (final concentration 50% vol/vol) obtained at stress (S-serum, squares) compared with sera obtained at baseline (B-serum, circles). ∗∗P <0.01. D, Serum epinephrine levels at stress (S) compared with levels at baseline (B) and follow-up (F). ∗P < .05 (n = 15). E, CD63 expression of basophils from 6 donors who did not participate in the TSST after stimulation with fMLP, stress serum (Serum) of 6 individuals participating in the TSST, epinephrine (Epin), and butoxamine (Butox). ∗∗P < .01 and ∗∗∗P < .001. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions


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