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Optimizing Aminoglycoside Use

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Presentation on theme: "Optimizing Aminoglycoside Use"— Presentation transcript:

1 Optimizing Aminoglycoside Use
William A. Craig, MD  Critical Care Clinics  Volume 27, Issue 1, Pages (January 2011) DOI: /j.ccc Copyright © Terms and Conditions

2 Fig. 1 The time course of killing and regrowth of Pseudomonas aeruginosa in thighs of neutropenic mice following 3 doses of tobramycin (TOB) in normal mice (left panel) and amikacin in mice with renal impairment (right panel). T>MIC, time above minimum inhibitory concentration. Critical Care Clinics  , DOI: ( /j.ccc ) Copyright © Terms and Conditions

3 Fig. 2 The relationship between different PK?PD indices and change in the number of bacteria in the thighs of neutropenic mice. The R2 value reflects the coefficient of determination. CFU, colony-forming units. Critical Care Clinics  , DOI: ( /j.ccc ) Copyright © Terms and Conditions

4 Fig. 3 The relationship between efficacy of aminoglycoside therapy in patients with gram-negative bacillary infections and the peak/MIC ratio. Critical Care Clinics  , DOI: ( /j.ccc ) Copyright © Terms and Conditions


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