1. Research and Discovery Grand Rounds January 17, 2018
Frontiers: University of Kansas Clinical and Translational Science Institute (KU CTSI)
Richard Barohn MD
Kim Kimminau PhD
William Brooks PhD

2. Frontiers: KU Clinical & Translational Science Institute
$25m over 5 years
Year 1=10 months (Sept 7, June 30, 2018)
Principal Investigator: Richard Barohn
Associate Directors: Kim Kimminau & William Brooks
Administrative Director: Jen Baker Assistant Administrative Director: Robin Liston

3. Frontiers: KU CTSI is a Regional Partnership
KUMC: Kansas City, Wichita, Salina
KU Lawrence
University of Missouri-Kansas City
Kansas City University of Medicine and Biosciences
The University of Kansas Health System (TUKHS)
Children's Mercy Kansas City
St. Luke's Health System
And soon: Kansas State University-College of Veterinarian Medicine

4. Frontiers: Organization

5. Stakeholder Engagement Advisory Board (SEAB)
Co-Chairs:
Tom Curran, PHD, FRS, Director, Children’s Mercy Kansas City
Cheryl Jernigan, CPA. FACHE, Lead Patient Advocate, KU Cancer Center and Frontiers
Members:
Abiodun Akinwuntan, PhD, MPH, MBA, Dean, KUMC School of Health Professions
Neeli Bendapudi, PhD, Provost and Executive Vice Chancellor, University of Kansas-Lawrence
John Carney, President and CEO, Center for Practical Bioethics
Wayne Carter, DVM, PhD, DAVCIM, President and CEO, Kansas City Area Life Sciences Institute
David Chao, PhD, President and CEO, Stowers Institute for Medical Research and BioMed Valley Discoveries, Inc.
Craig Dietz, DO, Chief Medical Officer, Kansas City CARE Clinic
Sally Dwyer, Director of Programs/Services, The ALS Association Mid-America Chapter and Director Midwest Neurology Alliance
Roy Jensen, MD, Director, KU Cancer Center
K. James Kallail, PhD, Associate Dean for Research, KUMC School of Medicine-Wichita
Steven Kanter, MD, Dean, UMKC School of Medicine
Ann Murguia, Elected Official, Commissioner Wyandotte County 3rd District
Bob Page, President and CEO, University of Kansas Hospital
Dominique Pahud, MBA, Founder & CEO Energizing Health
Kelly Ranallo, Founder/President, Turner Syndrome Global Alliance and Children’s Mercy Kansas City Family Advisory Board
Thomas Sack, PhD, President and CEO, MRIGlobal
Robert Simari, MD, Executive Dean, KUMC School of Medicine

6. External Advisory Board (EAB)
The EAB is comprised of nationally ranked clinical and translational investigators with CTSA expertise and community advocacy participants in our specific focus areas. Through annual meetings, the EAB provides guidance based on leadership experience at other CTSA hubs.
Members:
Bradley Evanoff, MD, MPH, Director, Institute for Clinical and Translational Sciences, Washington University
Gary Rosenthal, MD, Chair, Department of Internal Medicine, Wake Forest University
Julian Solway, MD, Director, Institute for Translational Medicine, University of Chicago
Consuelo Hopkins-Wilkins, MD, Executive Director, Meharry-Vanderbilt Alliance, Vanderbilt University and Meharry Medical College
Lucia Ohno-Machado, MD, MBA, PhD, Professor of Medicine and Founding Chair, Health System Department of Biomedical Informatics, University of California San Diego
Nicole Boice, Founder and CEO, Global Genes

7. FRONTIERS RESEARCH OUR THREE GOALS: SUPPORT researchers
TRAIN researchers
GROW the research enterprise
As a brief overview, this diagram depicts the 6 Cores that make up Frontiers
Each CORE is lead by experts in that particular field and has Navigators that serve as the conduit to the units specific resources. These Navigators work closely with each other to streamline activities and access for researchers.
The Administrative team can be viewed as the Gateway to accessing our Core Services and can help guide researchers to the resources or services needed.

8. FRONTIERS CORES EDUCATION & TRAINING COMMUNITY & COLLABORATION
BIOSTATISTICS & RESEARCH SUPPORT
INFORMATICS
CLINICAL STUDIES & RECRUITMENT STRATEGIES
ENTREPRENEURSHIP & INNOVATION
EDUCATION & TRAINING
ADMINISTRATION
As a brief overview, this diagram depicts the 6 Cores that make up Frontiers
Each CORE is lead by experts in that particular field and has Navigators that serve as the conduit to the units specific resources. These Navigators work closely with each other to streamline activities and access for researchers.
The Administrative team can be viewed as the Gateway to accessing our Core Services and can help guide researchers to the resources or services needed.

9. CORE LEADERS AND NAVIGATORS
Leadership
Navigators
Administration
Pilot Studies
Barohn, Brooks, Kimminau
Smith
Baker, Liston
Robertson
Entrepreneurship and Innovation
Weir, Nagel, Meyers
Schorno, Liston
Biostatistics and Research Support
Mayo, Caldwell, Blackwell
Tremblay, Griffith, Smilor
Community and Collaboration
Team Science
Greiner, Maliski, Berkley-Patton, Brooks, Kimminau
TBN
Education and Training
Ellerbeck, Choi, Leeder, Spertus
Kerling, Hindle, Farr
Informatics
Waitman
McMahon, Wennberg
Clinical Studies and Recruitment Strategies
Kluding, Burns
Lahner, TBN

10. NAVIGATORS Navigators will
Find collaborators, equipment, resources and information to help you develop and execute your research
Link you to additional expertise
For Navigator assistance, call

11. SUPPORT researchers with resources including:
Clinical and Translational Science Units (Fairway, Wichita, Children’s Mercy)
Biostatistics during project development and after successful funding
Regulatory issues and human subjects protection guidance
Links to community organizations for partnership and recruitment support
Help with reaching vulnerable and under-represented participants
Team science (brainstorming sessions; Design Studios)
Informatics including:
HERON - an open source framework to integrate data from diverse sources
REDCap for data management
Deep phenotyping, allowing access to data beyond the EHR like from wearable devices
Training and support to move entrepreneurial ideas to patent and commercialization

12. TRAIN researchers with resources including:
TL1 Trainees and KL2 Scholars program
New and improved Introduction to Clinical & Translational Research course
Partnering for Health conference (annually)
R & D Grand Rounds (monthly)
Informatics lunch & learns for HERON, REDCap and other tools
Research coordinator Bootcamp (monthly)
Research personnel (monthly)
GCP and RCR Training!

13. TRAIN researchers with resources including (con’t):
Biotech Startup School and entrepreneurship certificate program
Online training and short courses in biostatistics
Best practices for community and patient engagement; advise for engaging special populations
Bootcamp for investigators - under development

14. Additional resources include:
National Trial Innovation Network - for trial and recruitment support
National Center for Advancing Translational Science (NCATS) initiative to assist investigators in developing and implementing multi-center trials
Experts at Johns Hopkins, Vanderbilt, Tufts, Utah
Trial Innovation Center (TIC)
Recruitment Innovation Center (RIC)
Frontiers investigators apply for support through the Administrative Core
Trial Innovation Network website:

15. Research Funding Opportunities
Pilots
Clinical and Translational Pilot – Funding up to $20K ($170K annually)
Interinstitutional Pilot (Western States Pilot – ( ≤ $15K annually
Trailblazers
Arts+ Medicine Trailblazer - ≤ $5K annually
Biostatistics, Epidemiology and Research Design (BERD) Trailblazer – ≤ $20K ($50K annually)
Diversity Trailblazer – ≤ $2,500 ($20K annually)
Entrepreneurship Trailblazer - ≤ $5K ($20K annually)
Entrepreneur Tuition Voucher – Training available at KU and UMKC
Institute for Advancing Medical Innovation (IAMI) Trailblazer– ≤ $20K ($50K annually)
Lauren S. Aaronson PhD Trailblazer – ≤ $5K ($10K annually)

16. 2017 Stimulus Awardees - $170K Institution & Investigators
Project Title
Children’s Mercy - Pediatrics
Melissa Miller, MD
Enhanced Intervention to Improve Adolescent Outcomes: A Clinical Trial
Children’s Mercy – Pediatrics
Jennifer Schuster, MD
Evaluation of Neuraminidase Antibodies in Pediatric Stem Cell Transplant Patients Receiving High versus Standard Dose Influenza Vaccine
Children’s Mercy-Pediatrics / UMKC-Biomedical Sciences
Tamaroh Lewis, MD, PhD/Paula Nichols, PhD
Single Nucleotide Polymorphisms (SNPs) in Genes Responsible for Steroid Metabolism and Response in Preterm Infants with Bronchopulmonary Dysplasia
Saint Luke’s Hospital - Cardiology
John Spertus, MD, MPH
The Impact of i2b2 on Evaluation of the Primary Care Centered Lung Cancer Screening Protocol Using an Epic Application
KU – Physical Therapy
Neena Sharma, PhD, CMPT
Opioid and Rehabilitation Following Lumbar Spine Surgery
Catherine Siengsukon, PhD, MPT
Cognitive Behavioral Therapy for Insomnia to Address Insomnia Symptoms in People with Multiple Sclerosis
KU – Family Medicine
Crystal Lumpkins, PhD
Tribal and Urban Health Communication – Investigating how American Indian Leaders and Elders throughout the Midwest Perceive Themselves as Health Promoters
KU Wichita - Psychiatry
Matt Macaluso, DO
Augmentation versus Switch: Comparative Effectiveness Research Trial for Antidepressant Incomplete and Non-responders with Treatment Resistant Depression
KU – School of Nursing
Janet Pierce, PhD, MSN
Reducing Symptom Burden in Patients with Heart Failure with Preserved Ejection Fraction Using Ubiquinol
KU Lawrence – Life Span Institute
Matt Mosconi, PhD
Sensory and Motor Physiology in Autism

17. Predoctoral Trainee Scholars (TL1) – $69K
Institution & Scholar
Project Title
KU – School of Medicine
Natalie Eisenach
medical student, MSCR-candidate
Let’s talk about sex: Does language create a barrier to women reporting and receiving treatment for dyspareunia in the Spanish speaking community
UMKC – School of Medicine
Carlee Oakley
The direct effect of trimethylamine-n-oxide (TMAO) on cardia muscle contractile mechanics

18. Postdoctoral Trainee Scholars (TL1) – $274K
Institution & Scholar
Project Title
KU Lawrence – Life Span Institute
Kathryn Unruh, PhD
Systems Neuroscience Approaches to Studying Sensorimotor Behavior in Autism Spectrum Disorder
KU - Molecular and Integrative Physiology
Colin McCoin, PhD
Dose- and sex- dependence of reduced skeletal muscle mitochondrial function with statin therapy
KU – Surgery
Randi Ryan, MD
Use of patient-Derived Tissue in 3D Tissue Culture to Examine Repositioning of Ciclopirox Olamine for the Treatment of Esophageal Cancer
UMKC - Biomedical and Health Informatics
Natasha Aduloju-Ajihola, PhD
Religiosity Tailoring the ARTAS Strength-based System

19. Mentored Career Development Scholars (KL2) - $640K
Institution & Scholar
Project Title
Children’s Mercy - Clinical Pharmacy
John Wagner, DO
Statin Optimization in Pediatrics
KU Lawrence - Pharmacy Practice
Ryan Funk, PharmD, PhD
Metabolomic Markers of Methotrexate Response in Autoimmune Arthritis
KU - Cardiovascular Research Institute
Amanda Szabo-Reed, PhD
Examining the Influence of Metabolic Syndrome on the Executive Control Network, Cognition and Exercise Adherence in Older Adults
KU - Preventive Medicine and Public Health
Drew Roberts, PharmD, PhD
Patterns and predictors of risky opioid use among breast cancer survivors

20. BERD Trailblazer Awardees - $50K
Institution & Investigator
Project Title
KU - Biostatistics
Francisco Diaz, PhD
Decision Making in N‐of‐1 Clinical Trials
by Using Best Linear Unbiased Prediction and Benefit functions
Byron Gajewski, PhD
Designing and Analyzing Clinical Trials for Personalized Medicine (DACTPerM)
Jinxiang Hu, PhD
A novel hierarchical Bayesian CFA method for the development of the PROM, the hierarchical Bayesian Instrument Development (HBID), by including a hierarchical structure in the BID
Jonathan Mahnken, PhD
Re-examining Hypothesis Testing Paradigms for Modern Experiments with Multiple Outcomes
Milind Phadnis, PhD
Web application development for Phase-II clinical trials with time-to-event endpoint using novel statistical method utilizing the concept of Proportional Time

21. Diversity Trailblazer Awardees - $20K
Institution & Investigator
Project Title
KU – Physical Therapy
Sandra Billinger, PhD
Dose Response of Aerobic Exercise Post-Stroke (STEPSS trial)
KU – Hoglund Brain Imaging Center
Danielle Christifano, PhD
Identifying Strategies to Improve Recruitment and Retention of Pregnant African American Women in Phase III RCTs
Children’s Mercy - Pediatrics
Bridgette L. Jones, MD, MS
Engaging African American Children with Asthma into Clinical/Translational Research
KU - Alzheimer’s Disease Center
Jaime Perales Puchalt, PhD
Enhancing Latino enrollment in Alzheimer’s disease research though community partnership building
UMKC – Biomedical & Health Informatics
Jannette Berkley-Patton, PhD
Developing a Hepatitis C Virus (HCV) Testing and Linkage to Care Intervention in African American Churches Using a Faith-Health-Academic Engaged Approach
KU – School of Nursing
Sally Maliski, PhD, RN, FAAN
JUNTOS Against Cancer

22. Institute for Advancing Medical Innovation (IAMI) Trailblazer Awardees - $60K
Institution & Investigator
Project Title
KU – Neurology
Richard J. Barohn, MD / Laura Herbelin, BS
Therapy in Amyotrophic Lateral Sclerosis (TAME)
Omar Jawdat, MD
Trial of Oxaloacetate in ALS (TOALS)
KU – Internal Medicine
Tara Lin, MD
Research Concept Development for the Beat AML Consortium
KU - Neurology
Russell Swerdlow, MD
Pharmacokinetic Analysis of a Novel Bioenergetic Medicine Ester
KU – Physical Therapy - Hannes Devos, PhD / KU Deans Office - School of Health Professions Abiodun E. Akinwuntan, PhD MPH, MBA
A low cost Portable Driving Simulator (PDS)
Richard J. Barohn, MD/Laura Herbelin, BS

23. Lauren S. Aaronson Trailblazer Awardees - $20K
Institution & Investigator
Project Title
KU Lawrence – Speech, Language, Hearing
Nancy Brady, PhD
Implementation and Dissemination of the CCS
KU - Neurology
Kathleen Gustafson, PhD
Maternal and Fetal Reactions to Acute Emotional Stress in Depressed
Pregnant Women
KU – Hearing and Speech
Mindy Bridges, PhD
Reading Comprehension in Monolingual and Bilingual Students

24. Frontiers and Entrepreneurship
Institute for Advancing Medical Innovation (IAMI) Trailblazers
Entrepreneurship Roundtable – Led by Dr. Julie Nagel (KUMC) and Maria Meyers (UMKC); Coordinate training in Kansas and Missouri
Entrepreneurship Trailblazers
New Idea: Frontiers Discover/Innovation/Entrepreneurship Center in Briedenthal Incubator Building
Touch down space for KU Research Institute and KU Innovation and Collaboration to meet faculty
Faculty can get assistance with startup companies
Conference/meeting space for collision and team science
Coffee/beverages/food

25. Research Growth Goals Grow research: BIG growth goals:
Directly from CTSA
Pilots & Trailblazers lead to NIH grants
KL2 awardee expected to obtain independent NIH funding
TL1 post-doctoral trainees will obtain NIH funding
TL1 pre-doctoral trainees will start their research career
BIG growth goals:
Faculty recruitment
Space expansion
~$50M annual NIH funding before this grant
5 year goal = $65-$70M annual
10 year goal = $85-$100M annual
Frontiers is the infrastructure center for all types of translational research in the region

26. Questions?
Contact the Frontiers Administrative Core for assistance