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Arterioscler Thromb Vasc Biol

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1 Arterioscler Thromb Vasc Biol
Acute Antithrombotic Effect of a Front-Loaded Regimen of Clopidogrel in Patients With Atherosclerosis on Aspirin by Gérard Helft, Julio I. Osende, Stephen G. Worthley, Azfar G. Zaman, Oswaldo J. Rodriguez, Eli I. Lev, Michael E. Farkouh, Valentin Fuster, Juan J. Badimon, and James H. Chesebro Arterioscler Thromb Vasc Biol Volume 20(10): October 1, 2000 Copyright © American Heart Association, Inc. All rights reserved.

2 Effects of clopidogrel treatments on thrombus area.
Effects of clopidogrel treatments on thrombus area. Results on thrombus formation at baseline, 2 hours, and day 8 with the respective treatments. Data are expressed as mean thrombus area ±SEM (μm2). *P<0.05 vs baseline. Gérard Helft et al. Arterioscler Thromb Vasc Biol. 2000;20: Copyright © American Heart Association, Inc. All rights reserved.

3 Effects of clopidogrel treatments on platelet aggregation to ADP 5 μmol/L (A) and 10 μmol/L (B).
Effects of clopidogrel treatments on platelet aggregation to ADP 5 μmol/L (A) and 10 μmol/L (B). Results on maximal aggregation at baseline, 2 hours, 6 hours, day 2, and day 8 with the respective treatments. Data are expressed as mean percentage ±SEM. *P<0.05 vs baseline. †P<0.05 vs 2 hours. Gérard Helft et al. Arterioscler Thromb Vasc Biol. 2000;20: Copyright © American Heart Association, Inc. All rights reserved.

4 Effects of clopidogrel treatments on fibrinogen binding by flow cytometry induced by ADP 0.12 μmol/L (A) and 0.6 μmol/L (B). Effects of clopidogrel treatments on fibrinogen binding by flow cytometry induced by ADP 0.12 μmol/L (A) and 0.6 μmol/L (B). Results on activated platelets at baseline, 2 hours, day 2, and day 8 with the respective treatments. Data are expressed as the relative fibrinogen binding ±SEM compared with baseline. *P<0.05 vs baseline. Gérard Helft et al. Arterioscler Thromb Vasc Biol. 2000;20: Copyright © American Heart Association, Inc. All rights reserved.


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