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The effect of antiviral therapy on t(14;18) translocation and immunoglobulin gene rearrangement in patients with chronic hepatitis C virus infection by.

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Presentation on theme: "The effect of antiviral therapy on t(14;18) translocation and immunoglobulin gene rearrangement in patients with chronic hepatitis C virus infection by."— Presentation transcript:

1 The effect of antiviral therapy on t(14;18) translocation and immunoglobulin gene rearrangement in patients with chronic hepatitis C virus infection by Eli Zuckerman, Tsila Zuckerman, Dvora Sahar, Sara Streichman, Dina Attias, Edmond Sabo, Daniel Yeshurun, and Jacob M. Rowe Blood Volume 97(6): March 15, 2001 ©2001 by American Society of Hematology

2 The effect of antiviral treatment on immunoglobulin heavy-chain gene rearrangement in patients with chronic HCV infection.Detection of IgH rearrangement was performed by FW3/JH seminested PCR in PBMCs from patients with HCV-infected individuals. The effect of antiviral treatment on immunoglobulin heavy-chain gene rearrangement in patients with chronic HCV infection.Detection of IgH rearrangement was performed by FW3/JH seminested PCR in PBMCs from patients with HCV-infected individuals. Lanes 1 and 3: pretreatment bands represent the presence of IgH rearrangement; lane 2: disappearance of the band, indicating the loss of the proliferating B-cell clone upon completion of antiviral therapy. The patient had virologic response with clearance of HCV RNA at the end of treatment. Lane 4: persistence of the proliferative B-cell clone at the end of antiviral treatment. This patient had no virologic response. Lane 5: negative control; lane 6: positive control; lane 7: molecular weight marker. PCR products were separated on 2.5% agarose gel. Eli Zuckerman et al. Blood 2001;97: ©2001 by American Society of Hematology

3 The effect of antiviral treatment on t(14;18) translocation in patients with chronic HCV infection.Detection of t(14;18) translocation by MBR bcl-2/JH nested PCR in PBMCs from patients with chronic HCV infection before and after antiviral treatment. The effect of antiviral treatment on t(14;18) translocation in patients with chronic HCV infection.Detection of t(14;18) translocation by MBR bcl-2/JH nested PCR in PBMCs from patients with chronic HCV infection before and after antiviral treatment. Lanes 1 and 2: pretreatment t(14;18) translocation in this patient persisted upon completion of antiviral treatment. The patient had no virologic response; lanes 3 and 4: loss of pretreatment t(14;18) translocation in a patient who also had a virologic response to combination treatment with interferon-α and ribavirin; lane 5: negative control; lane 6: positive control (sample from a patient with follicular B-cell lymphoma); lane 7: molecular weight marker. PCR products were separated on 6% acrylamide gel. Eli Zuckerman et al. Blood 2001;97: ©2001 by American Society of Hematology

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