1. Gestora brasileiro focada exclusivamente na área da saúde.

2. The look of an investor:
Innovative technology, IP
Experienced team
Capital
Risks
Operational environment

3. Bridging the Gap between Academia and Industry:
Model for drug development in Brazil
Biopharmaceutical SA
Thomas Gerlach PhD

4. INNOVATION is global and happens everywhere
BIOZEUS
Copyright ©2014 BIOZEUS. All Rights Reserved.
INNOVATION is global and happens everywhere
Situation in Brazil today
High Discovery
Brazil world share of science publications is 2.2% (growth 32%) ( )
Low patent
Brazil world share of USPTO patents was 0.1% in 2008 and 2014
(0% growth)
Innovation occurs in countries independent of their wealth
UNESCO SCIENCE REPORT TOWARDS 2030) (2015)

5. BIGGEST CHALLENGE OF THE LIFE SCIENCES SECTOR
BIOZEUS
Copyright ©2014 BIOZEUS. All Rights Reserved.
BIGGEST CHALLENGE OF THE LIFE SCIENCES SECTOR
The drug development process starting from research to commercialization
is challenging as it is long, risky and expensive
Bridging the gap between academia and industry is difficult
UNESCO SCIENCE REPORT TOWARDS 2030) (2015)

6. Discovery & Preclinical
BIOZEUS
Copyright ©2014 BIOZEUS. All Rights Reserved.
PROFILE OF INVESTORS IN GLOBAL DRUG DEVELOPMENT
Clinical
Discovery & Preclinical
Regulatory Approval
Innovation
Phase I
Phase II
Phase III
PHARMA
Problem:
Death Valley
PHARMA
PHARMA
ACADEMIC
PHARMA
PUBLIC INV.
PUBLIC INV.
VENTURE
CAPITAL
PHARMA
VENTURE
CAPITAL
VENTURE
CAPITAL
GOVERN.
PUBLIC INV.
ACADEMIC
ACADEMIC
PUBLIC INV.
VENTURE
CAPITAL
GOVERN.
GOVERN.
ACADEMIC
VENTURE
CAPITAL
ACADEMIC
GOVERN.
GOVERN.

7. BRIDGING THE COMMERCIALIZATION GAP BETWEEN ACADEMIA AND INDUSTRY
BIOZEUS
Copyright ©2014 BIOZEUS. All Rights Reserved.
ABOUT BIOZEUS
BRIDGING THE COMMERCIALIZATION GAP BETWEEN ACADEMIA AND INDUSTRY
BIOZEUS was created by a Brazilian venture capital fund FinHealth…
...to translate promising innovative health research projects into new therapies that reach the global market
We license early-stage technologies from universities and research institutions and then develop them with the oversight of our experienced team and network of partners until proof of concept.

8. BUSSINESS DEVELOPMENT DEVELOPMENT SELECTION ACCESS
BIOZEUS
Copyright ©2014 BIOZEUS. All Rights Reserved.
BIOZEUS main activities
BUSSINESS
DEVELOPMENT
Partnership with biotech and pharma companies
DEVELOPMENT
SEVEN projects in-licensed
To lower risk and maximize the value of the asset
SELECTION
ANY therapeutic area
Analyzed more than 500 projects from academia
ACCESS
Partnership with more than 60 Brazilian institutes
Constant access to new research groups

9. BIOZEUS
Copyright ©2014 BIOZEUS. All Rights Reserved.
How BIOZEUS works
Selection and in-licensing promising Brazilian academic projects;
Expertise in translation of scientific research into human drugs;
Funding (coordinate multiple private and public funding sources);
Experienced project management;
Reach out to potential pharmaceutical and biotechnology industry partners/ licensees.

10. BIOZEUS
Copyright ©2014 BIOZEUS. All Rights Reserved.
GENERATING VALUE

11. BIOZEUS selecting criteria
Copyright ©2014 BIOZEUS. All Rights Reserved.
SELECTING PROJECTS
BIOZEUS selecting criteria
Good science addressing a real and global medical need
Isolated and characterized compound;
Mechanism of action elucidated
Possibility of international patent protection
Working across all therapeutic areas

12. BIOZEUS is not limited to a specific therapeutic area
Copyright ©2014 BIOZEUS. All Rights Reserved.
SELECTING PROJECTS
BIOZEUS is not limited to a specific therapeutic area

13. DEVELOPMENT: TEAM SELECTION
BIOZEUS
Copyright ©2014 BIOZEUS. All Rights Reserved.
DEVELOPMENT: TEAM SELECTION
CMC
ADME PD
TOX
CLINICAL TRIAL
REGULATORY
PATENT
MARKET

14. BIOZEUS ROLE IN INNOVATION IN BRAZIL
Copyright ©2014 BIOZEUS. All Rights Reserved.
BIOZEUS ROLE IN INNOVATION IN BRAZIL
Publicly funded research at Brazilian universities is generating every year discovery research and identification and validation of lead compounds for new drugs.
The university has not the expertise nor the funding to advance development beyond the early stages and most innovations are lost and will never be commercialized.
Biozeus bridges this commercialization gap by bringing together publicly funded health research, government and private investment and the pharmaceutical/ biotechnology industry.
Biozeus is helping to transform public investment in discovery research into viable commercial opportunities and will help to foster innovation in the pharmaceutical segment in Brazil.

15. Biopharmaceutical SA
THANK YOU